Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 1/20 | 0.59 |
| ▸ | LDHA | P00338 | 1/20 | 0.58 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.53 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.53 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.53 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.51 |
| ▸ | CDC25B | P30305 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9807649 | 0.86 | NCEH1 (0.51) | WDR5LDHANR4A1NR4A2NR4A3 | |
| SCHEMBL19695770 | 0.84 | NCEH1 (0.50) | WDR5LDHANR4A1NR4A2NR4A3 | |
| SCHEMBL7477120 | 0.84 | NCEH1 (0.54) | WDR5LDHANCEH1ALDH1A1KDM4E | |
| SCHEMBL14150964 | 0.83 | WDR5 (0.53) | WDR5LDHANR4A1NR4A2NR4A3 | |
| SCHEMBL11308992 | 0.82 | WDR5 (0.51) | WDR5LDHANR4A1NR4A2NR4A3 | |
| SCHEMBL12355057 | 0.80 | NCEH1 (0.47) | WDR5LDHANCEH1ALDH1A1KDM4E | |
| SCHEMBL7539671 | 0.80 | WDR5 (0.49) | WDR5LDHANR4A1NR4A2NR4A3 | |
| SCHEMBL8609970 | 0.79 | NCEH1 (0.44) | WDR5LDHANCEH1ALDH1A1KDM4E | |
| SCHEMBL28789417 | 0.78 | WDR5 (0.54) | WDR5LDHANR4A1NR4A2NR4A3 | |
| SCHEMBL21686452 | 0.78 | POLB (0.58) | LDHANR4A1NR4A2NR4A3CDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | WDR5 1650/4885LDHA 3048/4885NR4A1 3610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.