Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | FABP3 | P05413 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PHGDH | O43175 | 1/20 | 0.34 |
| ▸ | TPMT | P51580 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23809201 | 0.86 | ALDH1A1 (0.33) | HSD17B10ALDH1A1HPGDKDM4ETHRB | |
| SCHEMBL23809313 | 0.86 | HSD17B10 (0.46) | HSD17B10ALDH1A1HPGDKDM4EMCL1 | |
| SCHEMBL23809290 | 0.82 | KDM4E (0.54) | HSD17B10ALDH1A1HPGDKDM4EMCL1 | |
| SCHEMBL23809370 | 0.81 | DHODH (0.39) | HSD17B10ALDH1A1HPGDKDM4EMCL1 | |
| SCHEMBL26581225 | 0.80 | HSD17B10 (0.51) | HSD17B10ALDH1A1HPGDKDM4EMCL1 | |
| SCHEMBL23809489 | 0.79 | HSD17B10 (0.46) | HSD17B10ALDH1A1HPGDKDM4EMCL1 | |
| SCHEMBL23809518 | 0.78 | HSD17B10 (0.39) | HSD17B10ALDH1A1HPGDKDM4EMCL1 | |
| SCHEMBL23809284 | 0.78 | ALDH1A1 (0.38) | HSD17B10ALDH1A1HPGDKDM4EMCL1 | |
| SCHEMBL23809536 | 0.77 | ALDH1A1 (0.33) | HSD17B10ALDH1A1HPGDKDM4EMCL1 | |
| SCHEMBL23809171 | 0.76 | HSD17B10 (0.46) | HSD17B10ALDH1A1HPGDKDM4EMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | HSD17B10 3627/4885ALDH1A1 2556/4885HPGD 3190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.