Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.31 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23809170 | 0.86 | HSD17B10 (0.47) | ALDH1A1KDM4EHPGDHSD17B10THRB | |
| SCHEMBL26581378 | 0.80 | KDM4E (0.36) | ALDH1A1KDM4EHPGDHSD17B10THRB | |
| SCHEMBL23809496 | 0.80 | SLC9A1 (0.38) | HPGDSLC9A1PLA2G10LMNA | |
| SCHEMBL26037833 | 0.78 | THRB (0.36) | ALDH1A1KDM4EHPGDHSD17B10THRB | |
| SCHEMBL26581405 | 0.77 | KDM4E (0.33) | ALDH1A1KDM4EHPGDHSD17B10SLC9A1 | |
| SCHEMBL23809313 | 0.72 | HSD17B10 (0.46) | ALDH1A1KDM4EHPGDHSD17B10THRB | |
| SCHEMBL23809370 | 0.71 | DHODH (0.39) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL19478181 | 0.70 | GRM2 (0.44) | RXFP1 | |
| SCHEMBL9613264 | 0.69 | THRB (0.61) | ALDH1A1KDM4EHPGDHSD17B10THRB | |
| SCHEMBL23809290 | 0.69 | KDM4E (0.54) | ALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | ALDH1A1 2556/4885KDM4E 1156/4885HPGD 3190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.