Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 2/20 | 0.59 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | GLRA1 | P23415 | 2/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | EDNRA | P25101 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23809184 | 0.89 | SRD5A2 (0.46) | SRD5A2SRD5A1MCL1MAOBBCL2 | |
| SCHEMBL26581295 | 0.84 | SRD5A2 (0.62) | SRD5A2SRD5A1MEN1KMT2ANR4A2 | |
| SCHEMBL23809307 | 0.77 | SRD5A2 (0.50) | SRD5A2SRD5A1KMT2AGLRA1MRGPRX4 | |
| SCHEMBL23809181 | 0.76 | GPR35 (0.45) | SRD5A2SRD5A1MCL1 | |
| SCHEMBL23809310 | 0.75 | MCL1 (0.40) | MCL1MAOBL3MBTL1 | |
| SCHEMBL5005325 | 0.74 | SRD5A2 (0.61) | SRD5A2SRD5A1MEN1KMT2AMRGPRX4 | |
| SCHEMBL4470968 | 0.74 | SRD5A2 (1.00) | SRD5A2SRD5A1MEN1KMT2AMCL1 | |
| SCHEMBL20605152 | 0.74 | SRD5A2 (0.52) | SRD5A2SRD5A1MEN1KMT2ANPC1 | |
| SCHEMBL21647510 | 0.73 | SRD5A2 (0.54) | SRD5A2SRD5A1MEN1KMT2AGLRA1 | |
| SCHEMBL29715805 | 0.73 | SRD5A2 (0.54) | SRD5A2SRD5A1MEN1KMT2AGLRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | SRD5A2 4675/4885SRD5A1 4570/4885MEN1 3549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.