Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 3/20 | 0.50 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.50 |
| ▸ | GLRA1 | P23415 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26581296 | 0.85 | SRD5A2 (0.57) | SRD5A2SRD5A1KMT2AMRGPRX4RXRA | |
| SCHEMBL27252502 | 0.81 | SRD5A2 (0.50) | SRD5A2SRD5A1KMT2AMRGPRX4FOLH1 | |
| SCHEMBL23809247 | 0.77 | SRD5A2 (0.59) | SRD5A2SRD5A1GLRA1KMT2AMRGPRX4 | |
| SCHEMBL3160643 | 0.77 | SRD5A2 (0.61) | SRD5A2SRD5A1KMT2AMRGPRX4RXRA | |
| SCHEMBL5005325 | 0.74 | SRD5A2 (0.61) | SRD5A2SRD5A1KMT2AMRGPRX4NPC1 | |
| SCHEMBL23809185 | 0.74 | KMT2A (0.40) | SRD5A2SRD5A1KMT2AKDM4EHPGD | |
| SCHEMBL19332196 | 0.74 | SRD5A2 (0.58) | SRD5A2SRD5A1KMT2AMRGPRX4FOLH1 | |
| SCHEMBL23799927 | 0.74 | KMT2A (0.45) | SRD5A2SRD5A1KMT2AMRGPRX4FOLH1 | |
| SCHEMBL3918347 | 0.72 | GLRA1 (0.59) | GLRA1KMT2AMRGPRX4RXRANPC1 | |
| SCHEMBL7884800 | 0.72 | KMT2A (0.43) | SRD5A2SRD5A1KMT2AMRGPRX4FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | SRD5A2 4675/4885SRD5A1 4570/4885GLRA1 2944/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.