Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PHGDH | O43175 | 2/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23809489 | 0.90 | HSD17B10 (0.46) | ALDH1A1HSD17B10KDM4EHPGDSRD5A2 | |
| SCHEMBL23809517 | 0.86 | ALDH1A1 (0.38) | ALDH1A1HSD17B10KDM4EHPGDSRD5A2 | |
| SCHEMBL23809271 | 0.84 | KDM4E (0.41) | ALDH1A1HSD17B10KDM4EHPGDSRD5A2 | |
| SCHEMBL23809228 | 0.82 | KDM4E (0.43) | ALDH1A1HSD17B10KDM4EHPGDSRD5A2 | |
| SCHEMBL23809314 | 0.82 | KDM4E (0.41) | ALDH1A1KDM4EKMT2AMAPK1 | |
| SCHEMBL23809153 | 0.79 | HSD17B10 (0.36) | ALDH1A1HSD17B10KDM4EHPGDSRD5A2 | |
| SCHEMBL23809290 | 0.76 | KDM4E (0.54) | ALDH1A1HSD17B10KDM4EHPGDSRD5A2 | |
| SCHEMBL23809170 | 0.75 | HSD17B10 (0.47) | ALDH1A1HSD17B10KDM4EHPGDSRD5A2 | |
| SCHEMBL23809525 | 0.75 | HRH3 (0.41) | ALDH1A1HSD17B10KDM4EHPGDKMT2A | |
| SCHEMBL23809313 | 0.74 | HSD17B10 (0.46) | ALDH1A1HSD17B10KDM4EHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | ALDH1A1 2556/4885HSD17B10 3627/4885KDM4E 1156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.