Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | USP1 | O94782 | 2/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.33 |
| ▸ | LIPC | P11150 | 1/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23809299 | 0.89 | MEN1 (0.43) | MEN1KMT2ABCHEKDM4EALDH1A1 | |
| SCHEMBL23809525 | 0.81 | HRH3 (0.41) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL23809282 | 0.78 | ALDH1A1 (0.42) | KMT2AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL23809267 | 0.78 | HRH3 (0.43) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL23809489 | 0.76 | HSD17B10 (0.46) | KMT2AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL23809265 | 0.74 | PIK3CD (0.39) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL26048075 | 0.74 | ALDH1A1 (0.40) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL23809228 | 0.73 | KDM4E (0.43) | KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL23809497 | 0.71 | ALDH1A1 (0.36) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL26037572 | 0.71 | HRH3 (0.39) | MEN1KMT2AKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | MEN1 3549/4885KMT2A 824/4885BCHE 4716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.