⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL50388 | 1.00 | — | — | |
| SCHEMBL54852 | 1.00 | — | — | |
| 1,4-Butanediol SCHEMBL8983355 | 0.97 | TDP1 (0.44) | — | |
| SCHEMBL27787445 | 0.97 | — | — | |
| SCHEMBL28299896 | 0.97 | — | — | |
| 1,5-Pentanediol SCHEMBL6905317 | 0.94 | ALDH1A1 (0.43) | — | |
| 1,6-Hexanediol SCHEMBL7211787 | 0.94 | ALDH1A1 (0.43) | — | |
| SCHEMBL17686274 | 0.91 | TDP1 (0.40) | — | |
| SCHEMBL41064 | 0.90 | — | — | |
| SCHEMBL3401418 | 0.90 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115490708-B | Sulfonamide macrocyclic derivative, preparation method and application thereof | 苏州亚盛药业有限公司 | 2025-01-24 | — | — | CN | disclosed |
| CN-115490708-A | Sulfonamide macrocyclic derivatives, and preparation method and application thereof | 苏州亚盛药业有限公司 | 2022-12-20 | — | — | CN | disclosed |
| US-8450354-B2 | Substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutical compositions, and methods of use as β-secretase inhibitors | HIGH POINT PHARMACEUTICALS, LLC (US) | 2013-05-28 | — | — | US | disclosed |
| EP-2549874-A1 | SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS BETA-SECRETASE INHIBITORS | High Point Pharmaceuticals, LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| US-20110237570-A1 | SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS BETA-SECRETASE INHIBITORS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2011-09-29 | — | — | US | disclosed |
| US-7807426-B2 | Processes for producing optically active 1-substituted 2-methylpyrrolidine | KANEKA CORPORATION (JP) | 2010-10-05 | — | — | US | disclosed |
| EP-1735324-B1 | PREPARATION OF P-CHIROGENIC PHOSPHOLANES AND THEIR USE IN ASYMETRIC SYNTHESIS | WARNER LAMBERT CO (US) | 2008-08-20 | — | — | EP | disclosed |
| US-7390931-B2 | Preparation of P-chirogenic phospholanes and their use in asymmetric synthesis | PFIZER INC. (US) | 2008-06-24 | — | — | US | disclosed |
| US-20070292926-A1 | Processes for Producing Optically Active 1-Substituted 2-Methylpyrrolidine and Intermediate Therefor | KANEKA CORPORATION (JP) | 2007-12-20 | — | — | US | disclosed |
| US-20070149781-A1 | Process for preparing bisphospholane ligands | DEGUSSA AG (DE) | 2007-06-28 | — | — | US | disclosed |
| EP-1735324-A1 | PREPARATION OF P-CHIROGENIC PHOSPHOLANES AND THEIR USE IN ASYMETRIC SYNTHESIS | Warner-Lambert Company LLC (US) | 2006-12-27 | — | — | EP | disclosed |
| EP-1715054-A1 | PROCESSES FOR PRODUCING OPTICALLY ACTIVE 1-SUBSTITUTED 2-METHYLPYRROLIDINE AND INTERMEDIATE THEREFOR | KANEKA CORPORATION (JP) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005095424-A1 | PREPARATION OF P-CHIROGENIC PHOSPHOLANES AND THEIR USE IN ASYMETRIC SYNTHESIS | WARNER-LAMBERT COMPANY LLC (US) | 2005-10-13 | — | — | WO | disclosed |
| US-20050222464-A1 | Preparation of P-chirogenic phospholanes and their use in asymmetric synthesis | HOGE GARRETT S II | 2005-10-06 | — | — | US | disclosed |
| US-6103517-A | ECONOMICAL, SIMPLE PRODUCTION OF SECONDARY ALCOHOL CONTAINING ASSYMETRIC CARBON HAVING SUBSTITUTED METHYL GROUP AND HAVING ALKOXY AS TERMINAL GROUP BY ASSYMETRIC TRANSESTERIFICATION USING VINYL PROPIONATE AND LIPASE FROM CANDIDA ANTARCIA | MITSUBISHI GAS CHEMICAL COMPANY (JP) | 2000-08-15 | — | — | US | disclosed |