Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 3/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.38 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.38 |
| ▸ | PDE1A | P54750 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23809099 | 0.83 | ALDH1A1 (0.47) | KDM4EALDH1A1SMN1; SMN2HPGDTSHR | |
| SCHEMBL26037331 | 0.80 | SRD5A2 (0.45) | KDM4EALDH1A1SMN1; SMN2HPGDTSHR | |
| SCHEMBL23809144 | 0.77 | ALDH1A1 (0.45) | KDM4EALDH1A1SMN1; SMN2HPGDTSHR | |
| SCHEMBL23809163 | 0.74 | ALDH1A1 (0.48) | KDM4EALDH1A1SMN1; SMN2HPGDTSHR | |
| SCHEMBL23809353 | 0.74 | ALDH1A1 (0.44) | KDM4EALDH1A1SMN1; SMN2HPGDTSHR | |
| SCHEMBL23809222 | 0.73 | ALDH1A1 (0.44) | KDM4EALDH1A1SMN1; SMN2HPGDTSHR | |
| SCHEMBL26581299 | 0.73 | KDM4E (0.48) | KDM4EALDH1A1SMN1; SMN2HPGDTSHR | |
| SCHEMBL23809410 | 0.72 | KDM4E (0.45) | KDM4EALDH1A1SMN1; SMN2HPGDTSHR | |
| SCHEMBL23809173 | 0.72 | CNR2 (0.43) | KDM4EALDH1A1SMN1; SMN2HPGDTSHR | |
| SCHEMBL23809399 | 0.72 | KDM4E (0.46) | KDM4EALDH1A1SMN1; SMN2HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | KDM4E 1156/4885ALDH1A1 2556/4885SMN1; SMN2 1682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.