Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.39 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23809399 | 0.88 | KDM4E (0.46) | MAPK1KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL26037335 | 0.87 | SRD5A2 (0.47) | SRD5A2MAPK1KDM4EALDH1A1HPGD | |
| SCHEMBL23809144 | 0.85 | ALDH1A1 (0.45) | MAPK1KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL23809353 | 0.85 | ALDH1A1 (0.44) | MAPK1KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL23809222 | 0.84 | ALDH1A1 (0.44) | MAPK1KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL23809410 | 0.81 | KDM4E (0.45) | MAPK1KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL23809404 | 0.80 | KDM4E (0.42) | SRD5A2MAPK1KDM4EALDH1A1HPGD | |
| SCHEMBL26581355 | 0.76 | KDM4E (0.48) | MAPK1KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL23809474 | 0.76 | ALDH1A1 (0.46) | MAPK1KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL23809229 | 0.76 | MCL1 (0.36) | MAPK1KDM4EALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423435-B1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | UNIV VANDERBILT (US) | 2023-08-23 | — | — | EP | disclosed |