Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | USP1 | O94782 | 3/20 | 0.38 |
| ▸ | HTR1A | P08908 | 5/20 | 0.35 |
| ▸ | DRD4 | P21917 | 5/20 | 0.35 |
| ▸ | HTR1B | P28222 | 5/20 | 0.35 |
| ▸ | DRD3 | P35462 | 4/20 | 0.35 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
| ▸ | ICMT | O60725 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23809237 | 0.84 | DRD2 (0.43) | DRD2HTR2AUSP1HTR1ADRD4 | |
| SCHEMBL23809414 | 0.83 | HTR1A (0.42) | DRD2HTR2AHTR1ADRD4HTR1B | |
| SCHEMBL23809218 | 0.83 | DRD2 (0.42) | DRD2HTR2AUSP1HTR1ADRD4 | |
| SCHEMBL23809510 | 0.81 | GRIN2B (0.39) | USP1MCL1 | |
| SCHEMBL23809281 | 0.80 | MCL1 (0.42) | DRD2HTR2AUSP1HTR1ADRD4 | |
| SCHEMBL23809214 | 0.78 | MCL1 (0.41) | MCL1 | |
| SCHEMBL23809423 | 0.78 | MCL1 (0.42) | DRD2HTR2AMCL1ICMT | |
| SCHEMBL23809236 | 0.76 | GRIN2B (0.44) | MCL1 | |
| SCHEMBL20604926 | 0.71 | DRD2 (0.39) | DRD2HTR2AHTR1ADRD4HTR1B | |
| SCHEMBL20604874 | 0.71 | DRD2 (0.41) | DRD2HTR2AHTR1ADRD4HTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | DRD2 3801/4885HTR2A 1729/4885USP1 675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.