Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23809508 | 0.91 | KDM4E (0.48) | KDM4EMCL1SLC22A12S1PR3ALDH1A1 | |
| SCHEMBL26581620 | 0.88 | KDM4E (0.52) | KDM4EMCL1SLC22A12S1PR3ALDH1A1 | |
| SCHEMBL23809505 | 0.83 | KDM4E (0.56) | KDM4ESLC22A12ALDH1A1SMN1; SMN2ADRA1D | |
| SCHEMBL26581621 | 0.79 | KDM4E (0.50) | KDM4EMCL1SLC22A12ALDH1A1ADRA1D | |
| SCHEMBL23809399 | 0.79 | KDM4E (0.46) | KDM4EMCL1S1PR3ALDH1A1SMN1; SMN2 | |
| SCHEMBL26581613 | 0.77 | KDM4E (0.56) | KDM4EMCL1SLC22A12ALDH1A1SMN1; SMN2 | |
| SCHEMBL23809258 | 0.74 | MCL1 (0.41) | KDM4EMCL1ALDH1A1SMN1; SMN2ADRA1D | |
| SCHEMBL26581454 | 0.70 | KDM4E (0.66) | KDM4ESLC22A12ALDH1A1SMN1; SMN2ADRA1D | |
| SCHEMBL28265757 | 0.68 | SLC22A12 (0.74) | KDM4ESLC22A12ALDH1A1MAPK1MAPT | |
| SCHEMBL26581688 | 0.68 | MAPT (0.45) | MCL1ALDH1A1SMN1; SMN2TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | KDM4E 1156/4885MCL1 1/4885SLC22A12 3136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.