Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.56 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23809502 | 0.83 | KDM4E (0.49) | KDM4ESLC22A12ADRA1DALDH1A1HPGD | |
| SCHEMBL23809508 | 0.82 | KDM4E (0.48) | KDM4ESLC22A12ADRA1DALDH1A1KMT2A | |
| SCHEMBL26581454 | 0.78 | KDM4E (0.66) | KDM4ESLC22A12ADRA1DALDH1A1HPGD | |
| SCHEMBL26581613 | 0.77 | KDM4E (0.56) | KDM4ESLC22A12ADRA1DALDH1A1HPGD | |
| SCHEMBL23809353 | 0.76 | ALDH1A1 (0.44) | KDM4EALDH1A1HPGDKDM4CKMT2A | |
| SCHEMBL23809352 | 0.75 | KDM4E (0.43) | KDM4ESLC22A12ALDH1A1KMT2AMEN1 | |
| SCHEMBL26581620 | 0.73 | KDM4E (0.52) | KDM4ESLC22A12ADRA1DALDH1A1HPGD | |
| SCHEMBL28265757 | 0.73 | SLC22A12 (0.74) | KDM4ESLC22A12ALDH1A1KMT2AMEN1 | |
| SCHEMBL23809103 | 0.73 | KDM4E (0.42) | KDM4ESLC22A12ALDH1A1KMT2AMEN1 | |
| SCHEMBL23809436 | 0.72 | MAOB (0.42) | KDM4EALDH1A1SMN1; SMN2TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | KDM4E 1156/4885SLC22A12 3136/4885ADRA1D 4140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.