Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 19/20 | 0.64 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.53 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.53 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.53 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.53 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18987589 | 0.87 | HPGDS (0.75) | HPGDS | |
| SCHEMBL18987592 | 0.87 | HPGDS (0.75) | HPGDS | |
| SCHEMBL19021633 | 0.86 | HPGDS (0.47) | HPGDSBMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL23813028 | 0.80 | HPGDS (0.53) | HPGDS | |
| SCHEMBL531094 | 0.79 | HPGDS (0.72) | HPGDS | |
| SCHEMBL23812943 | 0.78 | HPGDS (1.00) | HPGDS | |
| SCHEMBL15681572 | 0.78 | TERT (0.56) | — | |
| SCHEMBL19020049 | 0.78 | HPGDS (0.53) | HPGDSBMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL19020865 | 0.76 | HPGDS (0.76) | HPGDS | |
| SCHEMBL5047611 | 0.75 | HPGDS (0.61) | HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3390384-B1 | QUINOLINE-3-CARBOXAMIDES AS H-PGDS INHIBITORS | ASTEX THERAPEUTICS LTD (GB) | 2021-09-15 | — | — | EP | disclosed |