Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPA5 | P11021 | 8/20 | 0.52 |
| ▸ | HSPA9 | P38646 | 5/20 | 0.52 |
| ▸ | HSPA2 | P54652 | 4/20 | 0.52 |
| ▸ | HSPA8 | P11142 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23804603 | 0.83 | HSPA5 (0.76) | HSPA5HSPA9HSPA2HSPA8HTT | |
| SCHEMBL23804600 | 0.83 | HSPA5 (0.76) | HSPA5HSPA9HSPA2HSPA8HTT | |
| SCHEMBL23804624 | 0.69 | HSPA5 (1.00) | HSPA5HSPA9HSPA2HSPA8HTT | |
| SCHEMBL23804620 | 0.69 | HSPA5 (1.00) | HSPA5HSPA9HSPA2HSPA8HTT | |
| SCHEMBL23804625 | 0.67 | HSPA5 (0.70) | HSPA5HSPA9HSPA2HSPA8HTT | |
| SCHEMBL23804622 | 0.67 | HSPA5 (0.70) | HSPA5HSPA9HSPA2HSPA8HTT | |
| SCHEMBL31105660 | 0.64 | GLA (0.58) | HSPA5HSPA9HSPA2HSPA8TP53 | |
| SCHEMBL1107000 | 0.63 | ADORA2A (0.68) | HSPA5HSPA9HSPA2HTTLMNA | |
| SCHEMBL3525492 | 0.63 | MTNR1A (0.50) | HTTSMN1; SMN2LMNA | |
| SCHEMBL5413640 | 0.63 | RAB9A (0.63) | L3MBTL1SMN1; SMN2LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021183942-A1 | INHIBITORS OF HSP70 PROTEINS | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2021-09-16 | — | — | WO | disclosed |