Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPA2 | P54652 | 3/20 | 0.48 |
| ▸ | HSPA8 | P11142 | 2/20 | 0.48 |
| ▸ | HSPA5 | P11021 | 4/20 | 0.46 |
| ▸ | HSPA9 | P38646 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | XIAP | P98170 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.32 |
| ▸ | MRE11 | P49959 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23818456 | 0.94 | HSPA8 (0.44) | HSPA2HSPA8HSPA5HSPA9ALDH1A1 | |
| SCHEMBL23804622 | 0.77 | HSPA5 (0.70) | HSPA2HSPA8HSPA5HSPA9ALDH1A1 | |
| SCHEMBL23804625 | 0.77 | HSPA5 (0.70) | HSPA2HSPA8HSPA5HSPA9ALDH1A1 | |
| SCHEMBL23818759 | 0.66 | HSPA5 (0.63) | HSPA2HSPA8HSPA5HSPA9SMN1; SMN2 | |
| SCHEMBL23818760 | 0.65 | HSPA5 (1.00) | HSPA2HSPA8HSPA5HSPA9ALDH1A1 | |
| SCHEMBL23804600 | 0.61 | HSPA5 (0.76) | HSPA2HSPA8HSPA5HSPA9ALDH1A1 | |
| SCHEMBL23804603 | 0.61 | HSPA5 (0.76) | HSPA2HSPA8HSPA5HSPA9ALDH1A1 | |
| SCHEMBL23804620 | 0.60 | HSPA5 (1.00) | HSPA2HSPA8HSPA5HSPA9ALDH1A1 | |
| SCHEMBL23804624 | 0.60 | HSPA5 (1.00) | HSPA2HSPA8HSPA5HSPA9ALDH1A1 | |
| SCHEMBL30492539 | 0.60 | HTT (0.61) | ALDH1A1SMN1; SMN2LMNAHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021183942-A1 | INHIBITORS OF HSP70 PROTEINS | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2021-09-16 | — | — | WO | disclosed |