Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPA5 | P11021 | 7/20 | 1.00 |
| ▸ | HSPA2 | P54652 | 4/20 | 0.67 |
| ▸ | HSPA9 | P38646 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23804610 | 0.86 | HSPA5 (0.76) | HSPA5HSPA2HSPA9RAB9AKMT2A | |
| SCHEMBL23818455 | 0.82 | HSPA5 (0.70) | HSPA5HSPA2HSPA9ALDH1A1RAB9A | |
| SCHEMBL23804616 | 0.80 | HSPA5 (1.00) | HSPA5HSPA2HSPA9ALDH1A1HTT | |
| SCHEMBL23804614 | 0.80 | HSPA5 (1.00) | HSPA5HSPA2HSPA9ALDH1A1HTT | |
| SCHEMBL23804612 | 0.80 | HSPA5 (1.00) | HSPA5HSPA2HSPA9ALDH1A1HTT | |
| SCHEMBL23804601 | 0.79 | HSPA5 (0.69) | HSPA5HSPA2HSPA9ALDH1A1RAB9A | |
| SCHEMBL23804598 | 0.79 | HSPA5 (0.69) | HSPA5HSPA2HSPA9ALDH1A1RAB9A | |
| SCHEMBL13222393 | 0.73 | HSPA5 (0.60) | HSPA5HSPA2HSPA9ALDH1A1RAB9A | |
| SCHEMBL3038955 | 0.73 | HSPA5 (0.60) | HSPA5HSPA2HSPA9ALDH1A1RAB9A | |
| SCHEMBL23818757 | 0.72 | CASP3 (0.66) | HSPA5HSPA2HSPA9ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021183942-A1 | INHIBITORS OF HSP70 PROTEINS | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2021-09-16 | — | — | WO | disclosed |