SCHEMBL2382016

SCHEMBL2382016

Ic1ccc(-c2nnc(-c3ccc(I)cc3)o2)cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APP P05067 2/20 0.70
NPC1 O15118 14/20 0.58
RAB9A P51151 14/20 0.58
SMN1; SMN2 Q16637 5/20 0.56
TP53 P04637 3/20 0.54
PKM P14618 1/20 0.54
SPHK2 Q9NRA0 1/20 0.53
HPGD P15428 3/20 0.50
KMT2A Q03164 3/20 0.50
NFKB1 P19838 2/20 0.50
NFKB2 Q00653 2/20 0.50
RELA Q04206 2/20 0.50
MEN1 O00255 2/20 0.50
POLB P06746 1/20 0.50
HSD17B10 Q99714 3/20 0.48
ALDH1A1 P00352 3/20 0.48
KDM4E B2RXH2 2/20 0.48
MAPT P10636 2/20 0.48
GLA P06280 1/20 0.48
ALOX15 P16050 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1836465 0.91 NPC1 (0.74) APPNPC1RAB9ASMN1; SMN2TP53
SCHEMBL2159951 0.86 NPC1 (0.74) APPNPC1RAB9ASMN1; SMN2TP53
SCHEMBL10112953 0.84 KDM4E (0.66) APPNPC1RAB9ASMN1; SMN2TP53
SCHEMBL1271099 0.84 APP (0.59) APPNPC1RAB9ASMN1; SMN2TP53
SCHEMBL12573308 0.84 APP (1.00) APPNPC1RAB9ASMN1; SMN2SPHK2
SCHEMBL12798171 0.82 NPC1 (0.74) APPNPC1RAB9ASMN1; SMN2SPHK2
SCHEMBL1423309 0.81 NPC1 (0.71) APPNPC1RAB9ASMN1; SMN2TP53
SCHEMBL11939392 0.80 GUSB (0.52) APPNPC1RAB9ASMN1; SMN2TP53
SCHEMBL22117179 0.80 HDAC6 (0.50) APPNPC1RAB9ASPHK2ALDH1A1
SCHEMBL31049648 0.80 NOTUM (0.68) APPNPC1RAB9ASMN1; SMN2SPHK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170271601-A1 Organic Light-Emitting Diode Materials UNITED STATES DEPARTMENT OF ENERGY 2017-09-21 US disclosed
US-8012528-B2 Applying a tetraaryldiamine compounds containing four acrylic or methacrylic ester groups, polymerizing the monomer; high reliability SEIKO EPSON CORPORATION (JP) 2011-09-06 US disclosed
US-20080107914-A1 Composition for Conductive Materials Comprising Tetra Acrylate Functionalised Arylamines, Conductive Material and Layer, Electronic Device and Equipment SEIKO EPSON CORPORATION (JP) 2008-05-08 US disclosed
WO-2006064892-A1 CONDUCTIVE MATERIAL, COMPOSITION FOR THE CONDUCTIVE MATERIAL, CONDUCTIVE LAYER, ELECTRONIC DEVICE, AND ELECTRONIC EQUIPMENT SEIKO EPSON CORPORATION (JP) 2006-06-22 WO disclosed
WO-2006043681-A1 COMPOSITION FOR CONDUCTIVE MATERIALS, CONDUCTIVE MATERIAL, CONDUCTIVE LAYER, ELECTRONIC DEVICE, AND ELECTRONIC EQUIPMENT SEIKO EPSON CORPORATION (JP) 2006-04-27 WO disclosed
WO-2006025612-A1 MATERIAL COMPOSITION FOR CONDUCTIVE LAYERS IN ELECTRONIC DEVICES SEIKO EPSON CORPORATION (JP) 2006-03-09 WO disclosed
WO-2006022439-A1 COMPOSITION FOR CONDUCTIVE MATERIALS COMPRISING TETRA ACRYLATE FUNCTIONALISED ARYLAMINES, CONDUCTIVE MATERIAL AND LAYER, ELECTRONIC DEVICE EQUIPMENT SEIKO EPSON CORPORATION (JP) 2006-03-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170271601-A1 Organic Light-Emitting Diode Materials SELE, DRD4, DRD1 APP 2946/4885NPC1 1620/4885RAB9A 1229/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.