SCHEMBL2382897

SCHEMBL2382897

CCCCCCCCCCCCOC(CCCCCCCCCCCC)OC(Oc1ccc(-c2nc(-c3ccc(C)cc3C)nc(-c3ccc(C)cc3C)n2)c(O)c1)C(C)O

nearest known ligand 0.36

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PLK1 P53350 3/20 0.36
CNR2 P34972 2/20 0.33
ENPP2 Q13822 1/20 0.32
PPARG P37231 2/20 0.32
PTPN11 Q06124 1/20 0.32
PPARA Q07869 1/20 0.32
PLA2G4B P0C869 1/20 0.31
ALPI P09923 1/20 0.31
THRA P10827 3/20 0.31
THRB P10828 2/20 0.31
STS P08842 2/20 0.31
SMPD1 P17405 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5081657 0.90 PLK1 (0.40) PLK1CNR2ENPP2PPARGPTPN11
SCHEMBL7744803 0.88 CNR2 (0.36) PLK1CNR2PTPN11STS
SCHEMBL8104548 0.88 PLK1 (0.36) PLK1CNR2ENPP2PPARGPTPN11
SCHEMBL38879 0.87 PLK1 (0.39) PLK1CNR2ENPP2PPARGPTPN11
SCHEMBL16163718 0.87 CNR2 (0.36) PLK1CNR2ENPP2PPARGPTPN11
SCHEMBL30575191 0.82 CNR1 (0.34) PLK1CNR2ENPP2
SCHEMBL7744799 0.82 CNR2 (0.38) PLK1CNR2PTPN11STS
SCHEMBL16163716 0.81 PLA2G4B (0.42) PLK1CNR2PTPN11PLA2G4B
SCHEMBL4562628 0.81 PLK1 (0.36) PLK1CNR2ENPP2PTPN11PLA2G4B
SCHEMBL10253638 0.81 CNR1 (0.36) PLK1CNR2PTPN11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8377192-B2 Stabilisers for inanimate organic materials BASF SE (DE) 2013-02-19 US disclosed
US-20110214590-A1 STABILISERS FOR INANIMATE ORGANIC MATERIALS BASF SE (DE) 2011-09-08 US disclosed
EP-1213283-B1 Biphenyl-substituted triazines as light stabilisers CIBA HOLDING INC (CH) 2009-04-29 EP disclosed
US-6919454-B2 Biphenyl-substituted triazines CIBA SPECIALTY CHEMICALS CORP. (US) 2005-07-19 US disclosed
US-20050019281-A1 Biphenyl-substituted triazines FLETCHER IAN JOHN (CH) 2005-01-27 US disclosed
US-6841670-B2 High thermal stability, are used as stabilizers for organic polymers to counter damage thereto caused by light, oxygen and heat, as light stabilizers for textile fiber materials and as sunscreens for the human skin. CIBA SPECIALTY CHEMICALS CORPORATION (US) 2005-01-11 US disclosed
US-6593403-B1 Additive mixture for improving the mechanical properties of polymers CIBA SPECIALTY CHEMICALS CORPORATION 2003-07-15 US disclosed
US-20030045444-A1 Biphenyl-substituted triazines FLETCHER IAN JOHN (CH) 2003-03-06 US disclosed
EP-0815089-B1 BIPHENYL-SUBSTITUTED TRIAZINES AS LIGHT STABILIZER CIBA SC HOLDING AG (CH) 2002-09-25 EP disclosed
EP-1213283-A2 Biphenyl-substituted triazines as light stabilisers Ciba SC Holding AG (CH) 2002-06-12 EP disclosed
US-6365653-B1 SUITABLE AS COLOUR-STABLE AND NONSTAINING STABILIZERS AND ANTIOZONANTS FOR PROTECTING NONBLACK ELASTOMERS AGAINST OXIDATIVE, THERMAL, LIGHT- OR OZONE-INDUCED DEGRADATION CIBA SPECIALTY CHEMICALS CORPORATION 2002-04-02 US disclosed
US-20010039341-A1 Biphenyl-Substituted Triazines FLETCHER IAN JOHN (CH) 2001-11-08 US disclosed
US-6255483-B1 USEFUL AS LIGHT STABILIZERS FOR TEXTILE FIBER MATERIALS AND SUNSCREENS FOR HUMAN SKIN CIBA SPECIALTY CHEMICALS CORPORATION 2001-07-03 US disclosed
EP-0815089-A1 BIPHENYL-SUBSTITUTED TRIAZINES AS LIGHT STABILIZER Ciba SC Holding AG (CH) 1998-01-07 EP disclosed
WO-1996028431-A1 BIPHENYL-SUBSTITUTED TRIAZINES AS LIGHT STABILIZER CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 1996-09-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110214590-A1 STABILISERS FOR INANIMATE ORGANIC MATERIALS C1S, C1R, F12 PLK1 4730/4885CNR2 262/4885ENPP2 585/4885
US-20050019281-A1 Biphenyl-substituted triazines TYR, AHR, CUTA PLK1 3368/4885CNR2 3692/4885ENPP2 4740/4885
US-20030045444-A1 Biphenyl-substituted triazines TYR, CYP1B1, NFE2L2 PLK1 3612/4885CNR2 3788/4885ENPP2 4845/4885
US-20010039341-A1 Biphenyl-Substituted Triazines TYR, CYP1B1, NFE2L2 PLK1 3612/4885CNR2 3788/4885ENPP2 4845/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.