Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 9/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.31 |
| ▸ | ALPG | P10696 | 2/20 | 0.31 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21712914 | 0.88 | KLKB1 (0.40) | KCNH2ALDH1A1KLKB1ALPGPLAA | |
| SCHEMBL23830157 | 0.87 | KCNH2 (0.43) | KCNH2ALDH1A1CRHR1 | |
| SCHEMBL23830217 | 0.87 | KCNH2 (0.38) | KCNH2ALDH1A1KLKB1ALPGPLAA | |
| SCHEMBL23830266 | 0.87 | KCNH2 (0.39) | KCNH2ALDH1A1KLKB1CRHR1 | |
| SCHEMBL23781336 | 0.84 | ALDH1A1 (0.43) | KCNH2ALDH1A1KLKB1ALPGPLAA | |
| SCHEMBL23830231 | 0.84 | ALDH1A1 (0.37) | KCNH2ALDH1A1 | |
| SCHEMBL23830226 | 0.81 | ALDH1A1 (0.37) | KCNH2ALDH1A1KLKB1 | |
| SCHEMBL23754040 | 0.76 | TRPV3 (0.34) | ALDH1A1KLKB1CYP1A2HPGDHSD17B10 | |
| SCHEMBL31357730 | 0.76 | TRPV3 (0.34) | ALDH1A1KLKB1CYP1A2HPGDHSD17B10 | |
| SCHEMBL23830264 | 0.75 | KLKB1 (0.33) | KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240076286-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2024-03-07 | — | — | US | disclosed |
| US-20240002363-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2024-01-04 | — | — | US | disclosed |
| US-11760745-B2 | Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2023-09-19 | — | — | US | disclosed |
| US-20210292301-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210292301-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KLKB1, KLK5, KLK1 | KCNH2 782/4885ALDH1A1 1223/4885KLKB1 1/4885 |
| US-11760745-B2 | Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors | KLKB1, KLK5, KLK1 | KCNH2 782/4885ALDH1A1 1223/4885KLKB1 1/4885 |
| US-20240002363-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KLKB1, KLK5, KLK1 | KCNH2 782/4885ALDH1A1 1223/4885KLKB1 1/4885 |
| US-20240076286-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KLKB1, KLK5, KLK1 | KCNH2 782/4885ALDH1A1 1223/4885KLKB1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.