SCHEMBL23831781

SCHEMBL23831781

CC(C)(C)[Si](C)(C)OCc1c(N)cccc1Cl

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.35
TSHR P16473 2/20 0.34
TAAR1 Q96RJ0 1/20 0.34
NR4A2 P43354 1/20 0.34
IDO1 P14902 4/20 0.34
GAA P10253 1/20 0.34
LMNA P02545 1/20 0.33
CCNA2 P20248 1/20 0.33
CDK2 P24941 1/20 0.33
CCNA1 P78396 1/20 0.33
CDK5 Q00535 1/20 0.33
CDK5R1 Q15078 1/20 0.33
MET P08581 1/20 0.32
KMT2A Q03164 1/20 0.32
MPO P05164 1/20 0.32
CYP3A4 P08684 1/20 0.31
PIK3CA P42336 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12228067 0.83 CD44 (0.37) TSHRCYP3A4PIK3CA
SCHEMBL22691803 0.81 IDO1 (0.33) IDO1
SCHEMBL17494714 0.81 KMT2A (0.47) ALDH1A1SMN1; SMN2TAAR1GAAKMT2A
SCHEMBL23831698 0.81 IDO1 (0.33) TAAR1IDO1
SCHEMBL1431414 0.81 IDO1 (0.33) IDO1
SCHEMBL17857273 0.79 IDO1 (0.38) SMN1; SMN2TAAR1IDO1
SCHEMBL5465261 0.78 IDO1 (0.41) ALDH1A1TAAR1IDO1GAAKMT2A
SCHEMBL23831681 0.78 IDO1 (0.31) IDO1
SCHEMBL31139989 0.77 NUDT1 (0.30) SMN1; SMN2
SCHEMBL18185048 0.77 ALDH1A1 (0.42) ALDH1A1SMN1; SMN2TSHRTAAR1NR4A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4121415-B1 INHIBITORS OF CYTOKININ OXIDASE DERIVED FROM 1-[2-(HYDROXYALKYL)PHENYL]-3-YLUREA, USE THEREOF AND PREPARATIONS CONTAINING THESE DERIVATIVES UNIV PALACKEHO (CZ) 2024-02-07 EP disclosed
EP-4121415-A1 INHIBITORS OF CYTOKININ OXIDASE DERIVED FROM 1-[2-(HYDROXYALKYL)PHENYL]-3-YLUREA, USE THEREOF AND PREPARATIONS CONTAINING THESE DERIVATIVES Univerzita Palackého v Olomouci (CZ) 2023-01-25 EP disclosed
WO-2021185391-A1 INHIBITORS OF CYTOKININ OXIDASE DERIVED FROM 1-[2-(HYDROXYALKYL)PHENYL]-3-YLUREA, USE THEREOF AND PREPARATIONS CONTAINING THESE DERIVATIVES UNIVERZITA PALACKEHO V OLOMOUCI (CZ) 2021-09-23 WO disclosed