SCHEMBL23832010

SCHEMBL23832010

COc1cccc(NC(=O)Nc2cc(F)ccc2CO)c1

nearest known ligand 0.61

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.61
MAPT P10636 7/20 0.60
MEN1 O00255 4/20 0.60
KMT2A Q03164 4/20 0.60
PTGER3 P43115 4/20 0.59
TP53 P04637 1/20 0.58
TSHR P16473 1/20 0.58
RAB9A P51151 4/20 0.57
ALDH1A1 P00352 3/20 0.57
HTT P42858 3/20 0.57
PKM P14618 2/20 0.56
MAPK1 P28482 1/20 0.56
NPC1 O15118 2/20 0.55
MITF O75030 1/20 0.54
CCR3 P51677 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30105020 1.00 SMN1; SMN2 (0.61) SMN1; SMN2MAPTMEN1KMT2APTGER3
SCHEMBL23831740 0.91 MAPT (0.58) SMN1; SMN2MAPTMEN1KMT2APTGER3
SCHEMBL30105279 0.91 MAPT (0.58) SMN1; SMN2MAPTMEN1KMT2APTGER3
SCHEMBL30105083 0.87 MEN1 (0.63) SMN1; SMN2MAPTMEN1KMT2APTGER3
SCHEMBL23831849 0.87 MEN1 (0.63) SMN1; SMN2MAPTMEN1KMT2APTGER3
SCHEMBL23832095 0.87 RAB9A (0.62) SMN1; SMN2MAPTMEN1KMT2APTGER3
SCHEMBL30105033 0.87 RAB9A (0.62) SMN1; SMN2MAPTMEN1KMT2APTGER3
SCHEMBL23832112 0.87 MAPT (0.72) SMN1; SMN2MAPTMEN1KMT2APTGER3
SCHEMBL30105126 0.87 MAPT (0.72) SMN1; SMN2MAPTMEN1KMT2APTGER3
SCHEMBL23831875 0.86 MAPT (0.55) SMN1; SMN2MAPTMEN1KMT2APTGER3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4121415-B1 INHIBITORS OF CYTOKININ OXIDASE DERIVED FROM 1-[2-(HYDROXYALKYL)PHENYL]-3-YLUREA, USE THEREOF AND PREPARATIONS CONTAINING THESE DERIVATIVES UNIV PALACKEHO (CZ) 2024-02-07 EP disclosed
EP-4121415-A1 INHIBITORS OF CYTOKININ OXIDASE DERIVED FROM 1-[2-(HYDROXYALKYL)PHENYL]-3-YLUREA, USE THEREOF AND PREPARATIONS CONTAINING THESE DERIVATIVES Univerzita Palackého v Olomouci (CZ) 2023-01-25 EP disclosed
WO-2021185391-A1 INHIBITORS OF CYTOKININ OXIDASE DERIVED FROM 1-[2-(HYDROXYALKYL)PHENYL]-3-YLUREA, USE THEREOF AND PREPARATIONS CONTAINING THESE DERIVATIVES UNIVERZITA PALACKEHO V OLOMOUCI (CZ) 2021-09-23 WO disclosed