Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | QPCT | Q16769 | 5/20 | 0.37 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.31 |
| ▸ | S100A9 | P06702 | 2/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4302790 | 0.77 | ALDH1A1 (0.43) | MMP12CDK1CHEK1PIM1AKT1 | |
| SCHEMBL19240443 | 0.75 | NQO2 (0.40) | AMY1ANPC1RAB9AKMT2AKDM4E | |
| SCHEMBL20551388 | 0.74 | NPSR1 (0.40) | MMP12QPCTSRCNPC1RAB9A | |
| SCHEMBL25349620 | 0.72 | PDPK1 (0.42) | MMP12QPCTQPCTLPDPK1PTK6 | |
| SCHEMBL25346767 | 0.70 | BRD4 (0.42) | S100A9KMT2A | |
| SCHEMBL17450949 | 0.70 | CA2 (0.42) | AMY1ACYP1A2CYP2C19ALDH1A1HSD17B10 | |
| SCHEMBL22699769 | 0.70 | KDM4E (0.41) | MMP12CHEK1PIM1AKT1FLT3 | |
| SCHEMBL11314846 | 0.69 | TDP1 (0.40) | MMP12CDK1CYP1A2CHEK1PIM1 | |
| SCHEMBL25343534 | 0.68 | AXL (0.53) | AMY1AS100A9NPC1RAB9AKDM4E | |
| SCHEMBL28798557 | 0.68 | SRC (0.56) | PDPK1SRCCYP1A2CHEK1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4121423-B1 | TETRAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2026-04-29 | — | — | EP | disclosed |
| EP-4121429-B1 | CONDENSED PYRIDINE DERIVATIVES SUBSTITUED BY AMIDE FUNCTIONS AS ACSS2 INHIBITORS | MERCK PATENT GMBH (DE) | 2025-08-13 | — | — | EP | disclosed |
| CN-115335371-B | Tetrazole derivatives | 默克专利股份公司 | 2024-12-27 | — | — | CN | disclosed |
| US-20240382468-A2 | TETRAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2024-11-21 | — | — | US | disclosed |
| US-20240009175-A9 | TETRAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2024-01-11 | — | — | US | disclosed |
| US-20230271956-A1 | AMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2023-08-31 | — | — | US | disclosed |
| US-20230271956-A1 | AMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2023-08-31 | — | — | US | disclosed |
| US-20230149371-A1 | TETRAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2023-05-18 | — | — | US | disclosed |
| US-20230149371-A1 | TETRAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2023-05-18 | — | — | US | disclosed |
| US-20230149371-A1 | TETRAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2023-05-18 | — | — | US | disclosed |
| EP-4121423-A1 | TETRAZOLE DERIVATIVES | Merck Patent GmbH (DE) | 2023-01-25 | — | — | EP | disclosed |
| EP-4121429-A1 | CONDENSED PYRIDINE DERIVASTIVES SUBSTITUED BY AMIDE FUNCTIONS AS ACSS2 INHIBITORS | Merck Patent GmbH (DE) | 2023-01-25 | — | — | EP | disclosed |
| CN-115443275-A | Condensed pyridine derivatives substituted with amide functions as ACSS2 inhibitors | 默克专利股份公司 | 2022-12-06 | — | — | CN | disclosed |
| CN-115335371-A | Tetrazole derivatives | 默克专利股份公司 | 2022-11-11 | — | — | CN | disclosed |
| WO-2021185793-A1 | TETRAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2021-09-23 | — | — | WO | disclosed |
| WO-2021185789-A1 | CONDENSED PYRIDINE DERIVASTIVES SUBSTITUED BY AMIDE FUNCTIONS AS ACSS2 INHIBITORS | MERCK PATENT GMBH (DE) | 2021-09-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240009175-A9 | TETRAZOLE DERIVATIVES | VHL, BRCA1, POT1 | MMP12 3195/4885QPCT 4372/4885QPCTL 4696/4885 |
| US-20240382468-A2 | TETRAZOLE DERIVATIVES | VHL, BRCA1, POT1 | MMP12 3195/4885QPCT 4372/4885QPCTL 4696/4885 |
| US-20230271956-A1 | AMIDE DERIVATIVES | BRCA1, HRAS, PCNA | MMP12 3172/4885QPCT 2481/4885QPCTL 3188/4885 |
| US-20230149371-A1 | TETRAZOLE DERIVATIVES | VHL, BRCA1, POT1 | MMP12 3195/4885QPCT 4372/4885QPCTL 4696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.