Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL4 | P05112 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.74 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.70 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.70 |
| ▸ | HPGD | P15428 | 7/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | MEN1 | O00255 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | GLA | P06280 | 2/20 | 0.59 |
| ▸ | CASP1 | P29466 | 2/20 | 0.59 |
| ▸ | CASP7 | P55210 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | PIM1 | P11309 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23833502 | 1.00 | IL4 (1.00) | IL4KDM4ETDP1ADORA1ADORA2A | |
| SCHEMBL31695332 | 0.88 | IL4 (0.78) | IL4KDM4ETDP1ADORA1ADORA2A | |
| SCHEMBL3371543 | 0.87 | ADORA1 (0.89) | IL4KDM4ETDP1ADORA1ADORA2A | |
| SCHEMBL23841221 | 0.87 | IL4 (0.77) | IL4KDM4ETDP1ADORA1ADORA2A | |
| SCHEMBL29331857 | 0.87 | IL4 (0.77) | IL4KDM4ETDP1ADORA1ADORA2A | |
| SCHEMBL31139632 | 0.86 | ADORA1 (0.78) | IL4KDM4ETDP1ADORA1ADORA2A | |
| SCHEMBL31139657 | 0.86 | KDM4E (1.00) | IL4KDM4ETDP1ADORA1ADORA2A | |
| SCHEMBL31695349 | 0.84 | IL4 (0.72) | IL4KDM4ETDP1ADORA1ADORA2A | |
| SCHEMBL31695325 | 0.84 | IL4 (0.72) | IL4KDM4ETDP1ADORA1ADORA2A | |
| SCHEMBL31695312 | 0.83 | ADORA1 (0.72) | IL4KDM4ETDP1ADORA1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240391913-A1 | SMALL MOLECULE INHIBITORS OF INTERLEUKIN-4 | TRUSTEES OF BOSTON UNIVERSITY (US) | 2024-11-28 | — | — | US | disclosed |
| US-12043621-B2 | Small molecule inhibitors of Interleukin-4 | TRUSTEES OF BOSTON UNIVERSITY (US) | 2024-07-23 | — | — | US | disclosed |
| US-20210317114-A1 | SMALL MOLECULE INHIBITORS OF INTERLEUKIN-4 | TRUSTEES OF BOSTON UNIVERSITY (US) | 2021-10-14 | — | — | US | disclosed |
| WO-2021188871-A1 | SMALL MOLECULE INHIBITORS OF INTERLEUKIN-4 | TRUSTEES OF BOSTON UNIVERSITY (US) | 2021-09-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12043621-B2 | Small molecule inhibitors of Interleukin-4 | IL4, IL2, IL4I1 | IL4 1/4885KDM4E 586/4885TDP1 4759/4885 |
| US-20240391913-A1 | SMALL MOLECULE INHIBITORS OF INTERLEUKIN-4 | IL4, IL2, IL4I1 | IL4 1/4885KDM4E 586/4885TDP1 4759/4885 |
| US-20210317114-A1 | SMALL MOLECULE INHIBITORS OF INTERLEUKIN-4 | IL4, IL2, IL4I1 | IL4 1/4885KDM4E 586/4885TDP1 4759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.