Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Decamethonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | ACHE | P22303 | 4/20 | 1.00 |
| ▸ | APEX1 | P27695 | 3/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | RAB9A | P51151 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.92 |
| ▸ | DNM1 | Q05193 | 6/20 | 0.73 |
| ▸ | APAF1 | O14727 | 1/20 | 0.65 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.65 |
| ▸ | RAD52 | P43351 | 1/20 | 0.65 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30019398 | 1.00 | MEN1 (1.00) | MEN1KMT2AACHEAPEX1NFKB1 | |
| SCHEMBL6933263 | 1.00 | MEN1 (1.00) | MEN1KMT2AACHEAPEX1NFKB1 | |
| SCHEMBL17898629 | 1.00 | MEN1 (1.00) | MEN1KMT2AACHEAPEX1NFKB1 | |
| SCHEMBL17898630 | 1.00 | MEN1 (1.00) | MEN1KMT2AACHEAPEX1NFKB1 | |
| SCHEMBL6931794 | 1.00 | MEN1 (1.00) | MEN1KMT2AACHEAPEX1NFKB1 | |
| SCHEMBL8208718 | 1.00 | MEN1 (1.00) | MEN1KMT2AACHEAPEX1NFKB1 | |
| SCHEMBL12126378 | 1.00 | MEN1 (1.00) | MEN1KMT2AACHEAPEX1NFKB1 | |
| Hexamethonium SCHEMBL34900 | 1.00 | MEN1 (1.00) | MEN1KMT2AACHEAPEX1NFKB1 | |
| Pentamethonium SCHEMBL61798 | 1.00 | MEN1 (1.00) | MEN1KMT2AACHEAPEX1NFKB1 | |
| SCHEMBL12198121 | 1.00 | MEN1 (1.00) | MEN1KMT2AACHEAPEX1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1266 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025049143-A1 | IONIZABLE PILLARARENE ANTICOAGULANT | UNIVERSITY OF MARYLAND, COLLEGE PARK (US) | 2025-03-06 | — | — | WO | claimed |
| US-11969451-B2 | Compositions and methods for treating the eye | Johnson & Johnson Surgical Vision, Inc. (US) | 2024-04-30 | — | — | US | claimed |
| EP-3481787-B1 | HALOGEN-FREE QUATERNARY AMINIES AND USES THEREOF | HUNTSMAN PETROCHEMICAL LLC (US) | 2024-02-28 | — | — | EP | claimed |
| US-11878041-B2 | Compositions and methods for treating the eye | Johnson & Johnson Surgical Vision, Inc. (US) | 2024-01-23 | — | — | US | claimed |
| US-20230101362-A1 | RNA STABILIZATION | TEAM MEDICAL LLC | 2023-03-30 | — | — | US | claimed |
| EP-1931320-B1 | MICROPARTICLES WITH MODIFIED RELEASE OF AT LEAST ONE ACTIVE PRINCIPLE AND ORAL DOSAGE FORM COMPRISING THE SAME | FLAMEL IRELAND LTD (IE) | 2022-06-15 | — | — | EP | claimed |
| US-11357805-B2 | Compositions and methods for treating the eye | Johnson & Johnson Surgical Vision, Inc. (US) | 2022-06-14 | — | — | US | claimed |
| US-20220047657-A1 | COMPOSITIONS AND METHODS FOR TREATING THE EYE | JOHNSON & JOHNSON SURGICAL VISION INC (US) | 2022-02-17 | — | — | US | claimed |
| US-11166997-B2 | Compositions and methods for treating the eye | Johnson & Johnson Surgical Vision, Inc. (US) | 2021-11-09 | — | — | US | claimed |
| US-20210292552-A1 | Functionalized Polyacrylate Polymer Compositions | HUNTSMAN INTERNATIONAL LLC | 2021-09-23 | — | — | US | claimed |
| US-20030091504-A1 | Method for controlling synthesis conditions during molecular sieve synthesis using combinations of quaternary ammonium hydroxides and halides | PASQUALE GARY (US) | 2003-05-15 | — | — | US | claimed |
| US-5770572-A | DETOXIFICATION WITH GENETIC ENGINEERED POLYPEPTIDE | YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD. (IL) | 1998-06-23 | — | — | US | claimed |
| CN-1131039-A | Polypeptide drug composition suitable for administration through eye and preparation method thereof | YONGGUANG PHARMACEUTICAL CO LT (CN) | 1996-09-18 | — | — | CN | claimed |
| EP-0329778-B1 | MOLECULAR DECOYANTS AND METHODS OF USE THEREOF | GERSHONI JONATHAN M (IL) | 1995-05-31 | — | — | EP | claimed |
| US-5283236-A | Inclusion of permeation-enhancing agent | ORBON CORPORATION (US) | 1994-02-01 | — | — | US | claimed |
| US-5192521-A | Synthesis of crystalline silicate ZSM-12 | MOBIL OIL CORP. (US) | 1993-03-09 | — | — | US | claimed |
| US-5182258-A | Passage into nasolacrimal duct and absorption into circulation | ORBON CORPORATION (US) | 1993-01-26 | — | — | US | claimed |
| EP-0329778-A4 | MOLECULAR DECOYANTS AND METHODS OF USE THEREOF | — | 1990-12-27 | — | — | EP | claimed |
| EP-0329778-A1 | MOLECULAR DECOYANTS AND METHODS OF USE THEREOF | GERSHONI, Jonathan M. (IL) | 1989-08-30 | — | — | EP | claimed |
| WO-1989001779-A1 | MOLECULAR DECOYANTS AND METHODS OF USE THEREOF | GERSHONI JONATHAN M (IL) | 1989-03-09 | — | — | WO | claimed |