Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 6/20 | 0.35 |
| ▸ | USP2 | O75604 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26171335 | 0.91 | CYP2D6 (0.40) | CYP2D6SMN1; SMN2KDM4EDRD2DRD3 | |
| SCHEMBL22856409 | 0.90 | DRD2 (0.42) | CYP2D6DRD2DRD3 | |
| SCHEMBL24508745 | 0.90 | DRD2 (0.36) | CYP2D6TSHRSMN1; SMN2KDM4EDRD2 | |
| SCHEMBL23560443 | 0.87 | TSHR (0.42) | CYP2D6USP2CYP3A4CYP1A2TSHR | |
| SCHEMBL21107120 | 0.87 | TSHR (0.41) | TSHRKDM4EDRD2DRD3 | |
| SCHEMBL23568282 | 0.84 | CYP2D6 (0.49) | CYP2D6USP2CYP3A4CYP1A2TSHR | |
| SCHEMBL26170521 | 0.84 | CYP2D6 (0.49) | CYP2D6USP2CYP3A4CYP1A2TSHR | |
| SCHEMBL23560445 | 0.84 | CYP2D6 (0.49) | CYP2D6USP2CYP3A4CYP1A2TSHR | |
| SCHEMBL25828370 | 0.84 | CYP2D6 (0.46) | CYP2D6USP2CYP3A4CYP1A2TSHR | |
| SCHEMBL24555490 | 0.82 | CYP2D6 (0.35) | CYP2D6USP2CYP3A4CYP1A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022147465-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-07-07 | — | — | WO | disclosed |
| WO-2021188948-A1 | MDM2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-09-23 | — | — | WO | disclosed |