Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.36 |
| ▸ | EBP | Q15125 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23842008 | 0.90 | CYP2D6 (0.35) | DRD2DRD3CYP2D6 | |
| SCHEMBL24508745 | 0.87 | DRD2 (0.36) | DRD2DRD3OPRM1OPRL1S1PR1 | |
| SCHEMBL25110219 | 0.85 | CYP2D6 (0.46) | DRD2DRD3OPRM1OPRL1S1PR1 | |
| SCHEMBL23560443 | 0.84 | TSHR (0.42) | CYP2D6 | |
| SCHEMBL20445417 | 0.82 | GNAI3 (0.45) | DRD2DRD3SIGMAR1 | |
| SCHEMBL13519627 | 0.82 | GNAI3 (0.45) | DRD2DRD3SIGMAR1 | |
| SCHEMBL23568282 | 0.81 | CYP2D6 (0.49) | CYP2D6 | |
| SCHEMBL26170521 | 0.81 | CYP2D6 (0.49) | CYP2D6 | |
| SCHEMBL26171335 | 0.80 | CYP2D6 (0.40) | DRD2DRD3CYP2D6 | |
| SCHEMBL22856559 | 0.80 | DRD2 (0.47) | DRD2DRD3OPRM1OPRL1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020264490-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-30 | — | — | WO | disclosed |