Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 8/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 8/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 8/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.34 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27171536 | 0.92 | CRBN (0.45) | DDB1CRBNIKZF1IKZF2 | |
| SCHEMBL23842385 | 0.90 | DDB1 (0.47) | DDB1CRBNOPRM1OPRL1OPRK1 | |
| SCHEMBL21996833 | 0.86 | DDB1 (0.52) | DDB1CRBN | |
| SCHEMBL31003851 | 0.85 | DDB1 (0.54) | DDB1CRBN | |
| SCHEMBL23832600 | 0.85 | DRD2 (0.41) | DDB1CRBNDRD2DRD3 | |
| SCHEMBL27171545 | 0.82 | DDB1 (0.46) | DDB1CRBNIKZF1IKZF2 | |
| SCHEMBL21997902 | 0.82 | DDB1 (0.44) | DDB1CRBN | |
| SCHEMBL26448008 | 0.80 | DDB1 (0.57) | DDB1CRBN | |
| SCHEMBL25934140 | 0.80 | CRBN (0.47) | DDB1CRBNIKZF1IKZF2 | |
| SCHEMBL21997035 | 0.79 | DDB1 (0.56) | DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021188948-A1 | MDM2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-09-23 | — | — | WO | disclosed |