Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 8/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5573660 | 0.87 | MEN1 (0.44) | MEN1KMT2AP2RY12DRD2DRD4 | |
| SCHEMBL2385186 | 0.86 | MEN1 (0.43) | MEN1KMT2AP2RY12DRD2DRD4 | |
| SCHEMBL2383147 | 0.86 | MEN1 (0.45) | MEN1KMT2AP2RY12DRD2DRD4 | |
| SCHEMBL12250952 | 0.84 | P2RY12 (0.41) | MEN1KMT2AP2RY12DRD2DRD4 | |
| SCHEMBL2384924 | 0.80 | PI4KB (0.44) | MEN1KMT2AP2RY12DRD2DRD4 | |
| SCHEMBL2384049 | 0.80 | DRD2 (0.48) | MEN1KMT2AP2RY12DRD2DRD4 | |
| SCHEMBL12250950 | 0.79 | PI4KB (0.43) | MEN1KMT2AP2RY12PDGFRBMAPK1 | |
| SCHEMBL2384354 | 0.78 | RAB9A (0.47) | P2RY12PDGFRBALDH1A1FAAHMAPT | |
| SCHEMBL2381747 | 0.78 | TRPV1 (0.47) | P2RY12PDGFRBFAAH | |
| SCHEMBL2423033 | 0.78 | KIT (0.48) | P2RY12PDGFRBHSD17B10ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8013156-B2 | Tie-2 modulators and methods of use | EXELIXIS, INC. (US) | 2011-09-06 | — | — | US | disclosed |