Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA4 | P22748 | 2/20 | 0.47 |
| ▸ | CA6 | P23280 | 2/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6440483 | 0.81 | PTGS2 (0.53) | PTGS1PTGS2NPC1RAB9AALDH1A1 | |
| SCHEMBL7802955 | 0.80 | PTGS2 (0.55) | PTGS1PTGS2NPC1RAB9AALDH1A1 | |
| SCHEMBL24866800 | 0.80 | PTGS2 (0.62) | PTGS1PTGS2NPC1RAB9AALDH1A1 | |
| SCHEMBL11793578 | 0.80 | CA1 (0.54) | PTGS1PTGS2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6963348 | 0.79 | LOXL2 (0.54) | NPC1ALDH1A1SMN1; SMN2KMT2ACA1 | |
| SCHEMBL2468497 | 0.78 | PTGS2 (0.63) | PTGS1PTGS2NPC1RAB9AALDH1A1 | |
| SCHEMBL7372634 | 0.78 | CA1 (0.56) | PTGS1PTGS2KMT2AOPRK1HTT | |
| SCHEMBL15874736 | 0.78 | CA1 (0.56) | PTGS1PTGS2KMT2AOPRK1HTT | |
| SCHEMBL11790802 | 0.77 | NPC1 (0.56) | PTGS1PTGS2NPC1RAB9AALDH1A1 | |
| SCHEMBL11794580 | 0.77 | ESR1 (0.56) | PTGS1PTGS2NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12048710-B2 | Compositions and methods for modification of biomolecules | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-07-30 | — | — | US | disclosed |
| US-20220202837-A1 | COMPOSITIONS AND METHODS FOR MODIFICATION OF BIOMOLECULES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2022-06-30 | — | — | US | disclosed |
| US-20220202837-A1 | COMPOSITIONS AND METHODS FOR MODIFICATION OF BIOMOLECULES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2022-06-30 | — | — | US | disclosed |
| US-11278554-B2 | Compositions and methods for modification of biomolecules | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-03-22 | — | — | US | disclosed |
| US-20210000965-A1 | ENRICHMENT-TRIGGERED CHEMICAL DELIVERY SYSTEM | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC (US) | 2021-01-07 | — | — | US | disclosed |
| US-20200046742-A1 | COMPOSITIONS AND METHODS FOR MODIFICATION OF BIOMOLECULES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-02-13 | — | — | US | disclosed |
| US-20200046742-A1 | COMPOSITIONS AND METHODS FOR MODIFICATION OF BIOMOLECULES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-02-13 | — | — | US | disclosed |
| US-10434111-B2 | Compositions and methods for modification of biomolecules | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-10-08 | — | — | US | disclosed |
| US-20160243135-A1 | Compositions and Methods for Modification of Biomolecules | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-08-25 | — | — | US | disclosed |
| US-20160243135-A1 | Compositions and Methods for Modification of Biomolecules | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-08-25 | — | — | US | disclosed |
| US-20110213123-A1 | COMPOSITIONS AND METHODS FOR MODIFICATION OF BIOMOLECULES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2011-09-01 | — | — | US | disclosed |
| US-20110213123-A1 | COMPOSITIONS AND METHODS FOR MODIFICATION OF BIOMOLECULES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2011-09-01 | — | — | US | disclosed |
| US-7807619-B2 | cycloalkyne compounds reacting with an azide moiety on a target biomolecule, by biochemical conjugation; for its application in vivo (on the cell surface or intracellularly) or in vitro (synthesis of peptides); labeling | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-10-05 | — | — | US | disclosed |
| US-7807619-B2 | cycloalkyne compounds reacting with an azide moiety on a target biomolecule, by biochemical conjugation; for its application in vivo (on the cell surface or intracellularly) or in vitro (synthesis of peptides); labeling | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-10-05 | — | — | US | disclosed |
| US-20090068738-A1 | COMPOSITIONS AND METHODS FOR MODIFICATION OF BIOMOLECULES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-03-12 | — | — | US | disclosed |
| US-20090068738-A1 | COMPOSITIONS AND METHODS FOR MODIFICATION OF BIOMOLECULES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-03-12 | — | — | US | disclosed |
| US-20090068738-A1 | COMPOSITIONS AND METHODS FOR MODIFICATION OF BIOMOLECULES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-03-12 | — | — | US | disclosed |
| EP-1812031-A2 | COMPOSITIONS AND METHODS FOR MODIFICATION OF BIOMOLECULES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-08-01 | — | — | EP | disclosed |
| US-20060110782-A1 | cycloalkyne compounds reacting with an azide moiety on a target biomolecule, by biochemical conjugation; for its application in vivo (on the cell surface or intracellularly) or in vitro (synthesis of peptides); labeling | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2006-05-25 | — | — | US | disclosed |
| WO-2006050262-A2 | COMPOSITIONS AND METHODS FOR MODIFICATION OF BIOMOLECULES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12048710-B2 | Compositions and methods for modification of biomolecules | PTMS, QPCT, ANPEP | PTGS1 2564/4885PTGS2 2726/4885NPC1 4502/4885 |
| US-20220202837-A1 | COMPOSITIONS AND METHODS FOR MODIFICATION OF BIOMOLECULES | PTMS, QPCT, ANPEP | PTGS1 2564/4885PTGS2 2726/4885NPC1 4502/4885 |
| US-10434111-B2 | Compositions and methods for modification of biomolecules | PTMS, QPCT, ANPEP | PTGS1 2564/4885PTGS2 2726/4885NPC1 4502/4885 |
| US-20090068738-A1 | COMPOSITIONS AND METHODS FOR MODIFICATION OF BIOMOLECULES | PTMS, QPCT, ANPEP | PTGS1 2564/4885PTGS2 2726/4885NPC1 4502/4885 |
| US-11278554-B2 | Compositions and methods for modification of biomolecules | PTMS, QPCT, ANPEP | PTGS1 2564/4885PTGS2 2726/4885NPC1 4502/4885 |
| US-20160243135-A1 | Compositions and Methods for Modification of Biomolecules | PTMS, QPCT, ANPEP | PTGS1 2564/4885PTGS2 2726/4885NPC1 4502/4885 |
| US-20110213123-A1 | COMPOSITIONS AND METHODS FOR MODIFICATION OF BIOMOLECULES | PTMS, QPCT, ANPEP | PTGS1 2564/4885PTGS2 2726/4885NPC1 4502/4885 |
| US-20200046742-A1 | COMPOSITIONS AND METHODS FOR MODIFICATION OF BIOMOLECULES | PTMS, QPCT, ANPEP | PTGS1 2564/4885PTGS2 2726/4885NPC1 4502/4885 |
| US-20210000965-A1 | ENRICHMENT-TRIGGERED CHEMICAL DELIVERY SYSTEM | HMGB1, PAICS, CCL2 | PTGS1 1219/4885PTGS2 1197/4885NPC1 1364/4885 |
| US-20060110782-A1 | cycloalkyne compounds reacting with an azide moiety on a target biomolecule, by biochemical conjugation; for its application in vivo (on the cell surface or intracellularly) or in vitro (synthesis of peptides); labeling | PTMS, QPCT, DNPEP | PTGS1 2434/4885PTGS2 2792/4885NPC1 4228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.