Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.41 |
| ▸ | CTSD | P07339 | 12/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2522306 | 0.81 | BACE1 (0.59) | BACE1CTSD | |
| SCHEMBL2515626 | 0.76 | BACE1 (0.36) | BACE1CTSD | |
| SCHEMBL8513311 | 0.69 | TRPA1 (0.35) | BACE1 | |
| SCHEMBL2371022 | 0.67 | BACE1 (0.54) | BACE1CTSD | |
| SCHEMBL3273289 | 0.67 | BACE1 (0.31) | BACE1ALOX5 | |
| SCHEMBL3273401 | 0.65 | PDK2 (0.41) | ALOX5 | |
| SCHEMBL3273686 | 0.64 | ALOX5 (0.41) | ALOX5 | |
| SCHEMBL2384529 | 0.64 | BACE1 (0.59) | BACE1CTSD | |
| SCHEMBL3291494 | 0.63 | CA1 (0.41) | BACE1CTSDALOX5 | |
| SCHEMBL2382599 | 0.63 | BACE1 (0.42) | BACE1CTSDALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547685-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS | Amgen Inc. (US) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011115938-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |