SCHEMBL23850128

SCHEMBL23850128

CCOC(=O)Cc1cccc(CSc2nc(-c3cccs3)c(C#N)c(=O)[nH]2)c1

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACMSD Q8TDX5 12/20 0.78
PRNP P04156 5/20 0.61
RXFP1 Q9HBX9 5/20 0.61
MEN1 O00255 5/20 0.61
KMT2A Q03164 5/20 0.61
NPSR1 Q6W5P4 4/20 0.61
POLB P06746 2/20 0.61
USP2 O75604 1/20 0.61
PKM P14618 1/20 0.61
BLM P54132 1/20 0.61
SAE1 Q9UBE0 1/20 0.61
UBA2 Q9UBT2 1/20 0.61
L3MBTL1 Q9Y468 1/20 0.61
CYP2C19 P33261 2/20 0.61
MAPT P10636 2/20 0.56
PSMD14 O00487 1/20 0.56
CYP1A2 P05177 1/20 0.56
CYP2C9 P11712 1/20 0.56
HPGD P15428 1/20 0.56
SERPINH1 P50454 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31053422 0.88 ACMSD (1.00) ACMSDPRNPRXFP1MEN1KMT2A
SCHEMBL17548496 0.88 ACMSD (1.00) ACMSDPRNPRXFP1MEN1KMT2A
SCHEMBL17548438 0.87 ACMSD (0.78) ACMSDPRNPRXFP1MEN1KMT2A
SCHEMBL24088169 0.87 ACMSD (0.58) ACMSDPRNPRXFP1MEN1KMT2A
SCHEMBL24088170 0.84 ACMSD (0.55) ACMSDPRNPRXFP1MEN1KMT2A
SCHEMBL26847147 0.84 ACMSD (0.85) ACMSDPRNPRXFP1MEN1KMT2A
SCHEMBL23850316 0.83 ACMSD (0.78) ACMSDPRNPRXFP1MEN1KMT2A
SCHEMBL31053420 0.83 ACMSD (0.78) ACMSDPRNPRXFP1MEN1KMT2A
SCHEMBL31053406 0.83 ACMSD (0.78) ACMSDPRNPRXFP1MEN1KMT2A
SCHEMBL23850223 0.83 ACMSD (0.78) ACMSDPRNPRXFP1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024240882-A1 HETEROARYL AND HETEROCYCLIC COMPOUNDS FOR USE IN TREATING ACUTE INFLAMMATION TES PHARMA S.R.L. (IT) 2024-11-28 WO disclosed
CN-118496217-A Inhibitors of alpha-amino-beta-carboxyhexadienoic acid semialdehyde decarboxylase TES制药有限责任公司 2024-08-16 CN disclosed
US-20230381177-A1 INHIBITORS OF ALPHA-AMINO-BETA-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE TES PHARMA S.R.L. (IT) 2023-11-30 US disclosed
US-20210379069-A1 INHIBITORS OF ALPHA-AMINO-BETA-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE TES PHARMA S R L (IT) 2021-12-09 US disclosed
EP-3883930-A1 INHIBITORS OF ALPHA-AMINO-BETA-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE Tes Pharma S.r.l. (IT) 2021-09-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230381177-A1 INHIBITORS OF ALPHA-AMINO-BETA-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE ACMSD, GLS, ALDH7A1 ACMSD 1/4885PRNP 569/4885RXFP1 4311/4885
US-20210379069-A1 INHIBITORS OF ALPHA-AMINO-BETA-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE ACMSD, GLS, ALDH7A1 ACMSD 1/4885PRNP 569/4885RXFP1 4311/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.