Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | TOP2A | P11388 | 2/20 | 0.34 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GALR3 | O60755 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21835474 | 0.84 | SMN1; SMN2 (0.38) | RAB9ASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL23850118 | 0.84 | TOP2A (0.33) | RAB9ASMN1; SMN2NPC1TOP2ATOP2B | |
| SCHEMBL23850108 | 0.75 | ALDH1A1 (0.38) | RAB9ASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL30450496 | 0.73 | KMT2A (0.37) | RAB9ANPC1MEN1KMT2APOLB | |
| SCHEMBL21835562 | 0.68 | SMN1; SMN2 (0.36) | SMN1; SMN2HTTKDM4EGALR3CYP1A2 | |
| SCHEMBL13799634 | 0.67 | HTT (0.40) | RAB9ASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL4163341 | 0.66 | CSNK2A1 (0.35) | RAB9ASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL9276114 | 0.66 | TOP2A (0.36) | RAB9ASMN1; SMN2NPC1TOP2ATOP2B | |
| SCHEMBL21835477 | 0.66 | SMN1; SMN2 (0.35) | SMN1; SMN2KDM4EALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL23850305 | 0.66 | HTT (0.37) | RAB9ASMN1; SMN2NPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3883573-A1 | MACROCYCLIC INHIBITORS OF DYRK1A | Dana-Farber Cancer Institute, Inc. (US) | 2021-09-29 | — | — | EP | disclosed |