Sugi Predict

Sugi Predict / Compounds / SCHEMBL4163341

SCHEMBL4163341

SCHEMBL4163341

Cc1c(Br)c(CO)nn1C

nearest known ligand 0.35

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ CSNK2A1 P68400 8/20 0.35
▸ CSNK2A2 P19784 2/20 0.35
▸ CSNK2B P67870 2/20 0.35
▸ CSNK2A3 Q8NEV1 2/20 0.35
▸ RAB9A P51151 3/20 0.33
▸ POLB P06746 2/20 0.33
▸ NPC1 O15118 1/20 0.33
▸ SMN1; SMN2 Q16637 2/20 0.33
▸ LMNA P02545 2/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ IDO1 P14902 1/20 0.33
▸ KDM4E B2RXH2 1/20 0.32
▸ GAA P10253 2/20 0.31
▸ HTR2A P28223 1/20 0.30
▸ HTR2C P28335 1/20 0.30
▸ TSHR P16473 1/20 0.30
▸ MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19497390 0.80 GAA (0.45) RAB9APOLBNPC1SMN1; SMN2LMNA
SCHEMBL22436865 0.80 GAA (0.32) RAB9APOLBNPC1SMN1; SMN2LMNA
SCHEMBL15622088 0.79 MEN1 (0.31) RAB9APOLBMEN1KMT2AKDM4E
SCHEMBL21729600 0.78 GAA (0.35) RAB9APOLBNPC1LMNAKDM4E
SCHEMBL26945695 0.77 GAA (0.38) IDO1KDM4EGAA
SCHEMBL13799634 0.76 HTT (0.40) RAB9APOLBNPC1SMN1; SMN2LMNA
SCHEMBL19635701 0.76 LMNA (0.34) CSNK2A1CSNK2A2CSNK2BCSNK2A3POLB
SCHEMBL19635567 0.75 CSNK2A1 (0.33) CSNK2A1CSNK2A2CSNK2BCSNK2A3IDO1
SCHEMBL19615636 0.75 IDO1 (0.37) CSNK2A1CSNK2A2CSNK2BCSNK2A3IDO1
SCHEMBL13184159 0.74 POLB (0.39) RAB9APOLBNPC1SMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 109 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250074920-A1 MACROCYCLIC COMPOUNDS AND USE AS KINASE INHIBITORS BLOSSOMHILL THERAPEUTICS INC (US) 2025-03-06 — — US disclosed
US-12195472-B2 Substituted indole Mcl-1 inhibitors VANDERBILT UNIVERSITY (US) 2025-01-14 — — US disclosed
US-12152041-B2 Macrocyclic fluorine substituted indole derivatives THE BROAD INSTITUTE, INC. (US) 2024-11-26 — — US disclosed
EP-4460498-A1 MACROCYCLIC COMPOUNDS AND USE AS KINASE INHIBITORS Blossomhill Therapeutics, Inc. (US) 2024-11-13 — — EP disclosed
US-11891404-B2 Substituted macrocyclic indole derivatives BAYER AKTIENGESELLSCHAFT (DE) 2024-02-06 — — US disclosed
CN-111757884-B Substituted macrocyclic indole derivatives 拜耳股份公司 2023-12-19 — — CN disclosed
WO-2023133375-A1 MACROCYCLIC COMPOUNDS AND USE AS KINASE INHIBITORS BLOSSOMHILL THERAPEUTICS, INC. (US) 2023-07-13 — — WO disclosed
WO-2023133375-A1 MACROCYCLIC COMPOUNDS AND USE AS KINASE INHIBITORS BLOSSOMHILL THERAPEUTICS, INC. (US) 2023-07-13 — — WO disclosed
CN-110536884-B Synthesis of MCL-1 inhibitors 阿斯利康(瑞典)有限公司 2023-05-02 — — CN disclosed
US-20230112244-A1 SUBSTITUTED MACROCYCLIC INDOLE DERIVATIVES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2023-04-13 — — US disclosed
US-20150284328-A1 7-SUBSTITUTED INDOLE MCL-1 INHIBITORS ABBVIE INC (US) 2015-10-08 — — US disclosed
WO-2015148854-A1 SUBSTITUTED INDOLE MCL-1 INHIBITORS VANDERBILT UNIVERSITY (US) 2015-10-01 — — WO disclosed
US-9035047-B2 7-substituted indole Mcl-1 inhibitors ABBVIE INC. (US) 2015-05-19 — — US disclosed
WO-2015031608-A1 SUBSTITUTED INDOLE MCL-1 INHIBITORS VANDERBILT UNIVERSITY (US) 2015-03-05 — — WO disclosed
WO-2014047427-A2 SUBSTITUTED BENZOFURAN, BENZOTHIOPHENE AND INDOLE MCL-1 INHIBITORS VANDERBILT UNIVERSITY (US) 2014-03-27 — — WO disclosed
US-20140051683-A1 7-SUBSTITUTED INDOLE MCL-1 INHIBITORS ABBVIE INC. (US) 2014-02-20 — — US disclosed
US-8445679-B2 7-substituted indole MCL-1 inhibitors ABBVIE INC. (US) 2013-05-21 — — US disclosed
EP-2134684-A2 7-SUBSTITUTED INDOLE MCL-1 INHIBITORS Abbott Laboratories (US) 2009-12-23 — — EP disclosed
US-20090054402-A1 7-SUBSTITUTED INDOLE MCL-1 INHIBITORS ABBOTT LABORATORIES (US) 2009-02-26 — — US disclosed
WO-2008131000-A2 7-SUBSTITUTED INDOLE MCL-1 INHIBITORS ABBOTT LABORATORIES (US) 2008-10-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230112244-A1 SUBSTITUTED MACROCYCLIC INDOLE DERIVATIVES FOXM1, CCND2, CCNI CSNK2A1 809/4885CSNK2A2 1001/4885CSNK2B 1018/4885
US-12152041-B2 Macrocyclic fluorine substituted indole derivatives FOXM1, CCNT2, CCND2 CSNK2A1 1702/4885CSNK2A2 1964/4885CSNK2B 1993/4885
US-11891404-B2 Substituted macrocyclic indole derivatives FOXM1, CCND2, CCNI CSNK2A1 809/4885CSNK2A2 1001/4885CSNK2B 1018/4885
US-20140051683-A1 7-SUBSTITUTED INDOLE MCL-1 INHIBITORS MCL1, BCL2L1, API5 CSNK2A1 1340/4885CSNK2A2 1393/4885CSNK2B 1319/4885
US-20250074920-A1 MACROCYCLIC COMPOUNDS AND USE AS KINASE INHIBITORS MAP3K20, MAP3K8, PRKACA CSNK2A1 378/4885CSNK2A2 371/4885CSNK2B 391/4885
US-12195472-B2 Substituted indole Mcl-1 inhibitors MCL1, BCL2L1, BCL3 CSNK2A1 1095/4885CSNK2A2 1115/4885CSNK2B 1104/4885
US-20150284328-A1 7-SUBSTITUTED INDOLE MCL-1 INHIBITORS MCL1, BCL2L1, API5 CSNK2A1 1340/4885CSNK2A2 1393/4885CSNK2B 1319/4885
US-20090054402-A1 7-SUBSTITUTED INDOLE MCL-1 INHIBITORS MCL1, BCL2L1, API5 CSNK2A1 1340/4885CSNK2A2 1393/4885CSNK2B 1319/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.