Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | HTR2B | P41595 | 3/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.33 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.32 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7518026 | 0.76 | PDPK1 (0.38) | TDP1AHRHTR2CHTR2BHTR2A | |
| SCHEMBL22463101 | 0.74 | ACHE (0.48) | ALDH1A1MAPTSMN1; SMN2TDP1KMT2A | |
| SCHEMBL18204501 | 0.74 | HTR2C (0.45) | SMN1; SMN2HTR2CHTR2BTAS1R3TAS1R1 | |
| SCHEMBL18204531 | 0.74 | HTR2C (0.45) | SMN1; SMN2HTR2CHTR2BTAS1R3TAS1R1 | |
| SCHEMBL8874724 | 0.73 | CYP19A1 (0.33) | ALDH1A1MAPTSMN1; SMN2TDP1HTR2C | |
| SCHEMBL17443406 | 0.72 | TSHR (0.38) | TDP1TAS1R3TAS1R1TAS1R2KMT2A | |
| SCHEMBL19899075 | 0.71 | TDP1 (0.40) | ALDH1A1MAPTTDP1TAS1R3TAS1R1 | |
| SCHEMBL27366970 | 0.71 | CYP19A1 (0.36) | THRBSMN1; SMN2TDP1NOTUMPDPK1 | |
| SCHEMBL3346153 | 0.71 | CYP19A1 (0.51) | ALDH1A1MAPTSMN1; SMN2TDP1HTR2C | |
| SCHEMBL29604926 | 0.71 | CYP19A1 (0.51) | ALDH1A1MAPTSMN1; SMN2TDP1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12209092-B2 | Inhibitors of GLI1 as therapeutic agents | NEW YORK UNIVERSITY (US) | 2025-01-28 | — | — | US | disclosed |
| EP-3883932-B1 | INHIBITORS OF GLI1 AS THERAPEUTIC AGENTS | UNIV NEW YORK (US) | 2023-03-29 | — | — | EP | disclosed |
| US-20220009935-A1 | INHIBITORS OF GLI1 AS THERAPEUTIC AGENTS | NEW YORK UNIVERSITY | 2022-01-13 | — | — | US | disclosed |
| EP-3883932-A1 | INHIBITORS OF GLI1 AS THERAPEUTIC AGENTS | New York University (US) | 2021-09-29 | — | — | EP | disclosed |
| CN-113316577-A | GLi1 inhibitors as therapeutic agents | 纽约大学 | 2021-08-27 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12209092-B2 | Inhibitors of GLI1 as therapeutic agents | GLI1, GLI2, SHH | ALDH1A1 1281/4885MAPT 2297/4885THRB 1855/4885 |
| US-20220009935-A1 | INHIBITORS OF GLI1 AS THERAPEUTIC AGENTS | GLI1, GLI2, SHH | ALDH1A1 1281/4885MAPT 2297/4885THRB 1855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.