Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 1.00 |
| ▸ | AMY1A | P0DUB6 | 6/20 | 0.71 |
| ▸ | MGAM | O43451 | 10/20 | 0.71 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | FLT3 | P36888 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31238963 | 1.00 | RORC (1.00) | RORCAMY1AMGAMMAPTALDH1A1 | |
| SCHEMBL5457779 | 0.77 | RAB9A (1.00) | RORCAMY1AMGAMMAPTALDH1A1 | |
| SCHEMBL3913279 | 0.76 | MAPT (0.72) | RORCAMY1AMGAMMAPTALDH1A1 | |
| SCHEMBL23850168 | 0.76 | RORC (1.00) | RORCAMY1AMGAMMAPTALDH1A1 | |
| SCHEMBL23850800 | 0.75 | RORC (1.00) | RORCAMY1AMGAMMAPTALDH1A1 | |
| SCHEMBL23850798 | 0.75 | RORC (1.00) | RORCAMY1AMGAMMAPTALDH1A1 | |
| SCHEMBL2132168 | 0.74 | MAPT (0.78) | RORCAMY1AMGAMMAPTALDH1A1 | |
| SCHEMBL31238948 | 0.74 | RORC (0.59) | RORCAMY1AMGAMMAPTALDH1A1 | |
| SCHEMBL8290375 | 0.74 | MAPT (0.84) | RORCAMY1AMGAMMAPTALDH1A1 | |
| SCHEMBL23850170 | 0.73 | RORC (1.00) | RORCAMY1AMGAMMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3883929-A1 | 4,5,6,7-TETRAHYDRO-L-BENZOTHIOPHENE MODULATORS OF RETINOIC ACID RECEPTOR RELATED (RAR) ORPHAN NUCLEAR RECEPTORS (RORS) | 11949098 Canada Inc. (CA) | 2021-09-29 | — | — | EP | claimed |
| CN-113166130-A | 4,5,6, 7-tetrahydro-L-benzothiophene modulators of retinoic acid receptor-associated (RAR) orphan nuclear receptors (ROR) | 11949098加拿大股份有限公司 | 2021-07-23 | — | — | CN | claimed |
| EP-3883929-A1 | 4,5,6,7-TETRAHYDRO-L-BENZOTHIOPHENE MODULATORS OF RETINOIC ACID RECEPTOR RELATED (RAR) ORPHAN NUCLEAR RECEPTORS (RORS) | 11949098 Canada Inc. (CA) | 2021-09-29 | — | — | EP | disclosed |
| CN-113166130-A | 4,5,6, 7-tetrahydro-L-benzothiophene modulators of retinoic acid receptor-associated (RAR) orphan nuclear receptors (ROR) | 11949098加拿大股份有限公司 | 2021-07-23 | — | — | CN | disclosed |