Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | HAO1 | Q9UJM8 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1930167 | 0.88 | KDM4C (0.53) | KDM4CNPSR1MAPK1ALDH1A1LMNA | |
| SCHEMBL5185712 | 0.85 | KDM4C (0.46) | KDM4CNPSR1MAPK1HAO1LMNA | |
| Water SCHEMBL6474736 | 0.77 | LDHA (0.37) | MAPK1HAO1HCAR2 | |
| SCHEMBL19661284 | 0.77 | KDM4C (0.46) | KDM4CNPSR1MAPK1ALDH1A1LMNA | |
| SCHEMBL9587880 | 0.76 | KDM4C (0.44) | KDM4CNPSR1MAPK1ALDH1A1LMNA | |
| SCHEMBL23294432 | 0.74 | KDM4C (0.43) | KDM4CNPSR1MAPK1ALDH1A1LMNA | |
| SCHEMBL3958675 | 0.74 | KDM4C (0.43) | KDM4CNPSR1MAPK1ALDH1A1LMNA | |
| SCHEMBL9642740 | 0.74 | KDM4C (0.43) | KDM4CNPSR1MAPK1HAO1ALDH1A1 | |
| SCHEMBL21621355 | 0.74 | KDM4C (0.43) | KDM4CNPSR1MAPK1ALDH1A1GAA | |
| SCHEMBL23608732 | 0.72 | HAO1 (0.35) | HAO1LMNAHCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552918-B1 | N-(IMIDAZOPYRIMIDIN-7-YL)-HETEROARYLAMIDE DERIVATIVES AND THEIR USE AS PDE10A INHIBITORS | HOFFMANN LA ROCHE (CH) | 2014-06-11 | — | — | EP | disclosed |
| US-8410117-B2 | Imidazopyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2013-04-02 | — | — | US | disclosed |
| EP-2552918-A1 | N-(IMIDAZOPYRIMIDIN-7-YL)-HETEROARYLAMIDE DERIVATIVES AND THEIR USE AS PDE10A INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2013-02-06 | — | — | EP | disclosed |
| CN-102232069-A | N-acetylneuraminic acid compound, pharmaceutical composition thereof, preparation method and application thereof | SHANGHAI INST MATERIA MEDICA | 2011-11-02 | — | — | CN | disclosed |
| US-20110237564-A1 | IMIDAZOPYRIMIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. | 2011-09-29 | — | — | US | disclosed |
| WO-2011117264-A1 | N-(IMIDAZOPYRIMIDIN-7-YL)-HETEROARYLAMIDE DERIVATIVES AND THEIR USE AS PDE10A INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-09-29 | — | — | WO | disclosed |
| CN-100548992-C | The 1,2,3-triazoles derivative of microbicidel (for example sterilization) | SYNGENTA PARTICIPATIONS AG (CH) | 2009-10-14 | — | — | CN | disclosed |
| CN-1678593-A | Microbiocidal (e.g. fungicidal) 1,2,3-triazole derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2005-10-05 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237564-A1 | IMIDAZOPYRIMIDINE DERIVATIVES | PDE5A, PDE3B, PDE3A | KDM4C 1702/4885NPSR1 1343/4885MAPK1 1885/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.