Clarithromycin

SCHEMBL23854898

CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O.CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O.CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Clarithromycin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	CYP3A4	P08684	9/20	1.00

▸	KCNH2	Q12809	5/20	1.00

▸	ABCB1	P08183	2/20	1.00

▸	SLCO1B3	Q9NPD5	2/20	1.00

▸	SLCO1B1	Q9Y6L6	2/20	1.00

▸	AR	P10275	1/20	1.00

▸	MAPK1	P28482	1/20	1.00

▸	MLNR	O43193	2/20	0.92

▸	TSHR	P16473	2/20	0.92

▸	LMNA	P02545	2/20	0.92

▸	TDP1	Q9NUW8	1/20	0.92

▸	ALB	P02768	1/20	0.92

▸	CNR1	P21554	1/20	0.92

▸	HTR2A	P28223	1/20	0.92

▸	AOX1	Q06278	1/20	0.92

▸	CYP1B1	Q16678	1/20	0.92

▸	ABCC4	O15439	1/20	0.77

▸	ABCB11	O95342	1/20	0.77

▸	PGR	P06401	1/20	0.77

▸	HTR1A	P08908	1/20	0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Clarithromycin SCHEMBL13575758	1.00	CYP3A4 (1.00)	CYP3A4KCNH2ABCB1SLCO1B3SLCO1B1
Clarithromycin SCHEMBL13300525	1.00	CYP3A4 (1.00)	CYP3A4KCNH2ABCB1SLCO1B3SLCO1B1
Clarithromycin SCHEMBL13374687	1.00	CYP3A4 (1.00)	CYP3A4KCNH2ABCB1SLCO1B3SLCO1B1
Clarithromycin SCHEMBL19585126	1.00	CYP3A4 (1.00)	CYP3A4KCNH2ABCB1SLCO1B3SLCO1B1
Clarithromycin SCHEMBL24064961	1.00	CYP3A4 (1.00)	CYP3A4KCNH2ABCB1SLCO1B3SLCO1B1
Clarithromycin SCHEMBL15474392	1.00	CYP3A4 (1.00)	CYP3A4KCNH2ABCB1SLCO1B3SLCO1B1
Clarithromycin SCHEMBL23309064	1.00	CYP3A4 (1.00)	CYP3A4KCNH2ABCB1SLCO1B3SLCO1B1
Clarithromycin SCHEMBL14342512	1.00	CYP3A4 (1.00)	CYP3A4KCNH2ABCB1SLCO1B3SLCO1B1
Clarithromycin SCHEMBL38124	1.00	CYP3A4 (1.00)	CYP3A4KCNH2ABCB1SLCO1B3SLCO1B1
Clarithromycin SCHEMBL14495684	1.00	CYP3A4 (1.00)	CYP3A4KCNH2ABCB1SLCO1B3SLCO1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-11938184-B2	Compositions and methods for treating Crohn's Disease and related conditions and infections	Agrawal, Gaurav (AU)	2024-03-26	—	—	US	disclosed
US-20210299254-A1	COMPOSITIONS AND METHODS FOR TREATING CROHN'S DISEASE AND RELATED CONDITIONS AND INFECTIONS	CENTRE FOR DIGESTIVE DISEASES (AU)	2021-09-30	—	—	US	disclosed