Known targets — ChEMBL curated mechanism
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The experimentally established mechanism targets of Clarithromycin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 9/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 5/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 2/20 | 1.00 |
| ▸ | SLCO1B3 | Q9NPD5 | 2/20 | 1.00 |
| ▸ | SLCO1B1 | Q9Y6L6 | 2/20 | 1.00 |
| ▸ | AR | P10275 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | MLNR | O43193 | 2/20 | 0.92 |
| ▸ | TSHR | P16473 | 2/20 | 0.92 |
| ▸ | LMNA | P02545 | 2/20 | 0.92 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.92 |
| ▸ | ALB | P02768 | 1/20 | 0.92 |
| ▸ | CNR1 | P21554 | 1/20 | 0.92 |
| ▸ | HTR2A | P28223 | 1/20 | 0.92 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.92 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.92 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.77 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.77 |
| ▸ | PGR | P06401 | 1/20 | 0.77 |
| ▸ | HTR1A | P08908 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clarithromycin SCHEMBL13300525 | 1.00 | CYP3A4 (1.00) | CYP3A4KCNH2ABCB1SLCO1B3SLCO1B1 | |
| Clarithromycin SCHEMBL13374687 | 1.00 | CYP3A4 (1.00) | CYP3A4KCNH2ABCB1SLCO1B3SLCO1B1 | |
| Clarithromycin SCHEMBL19585126 | 1.00 | CYP3A4 (1.00) | CYP3A4KCNH2ABCB1SLCO1B3SLCO1B1 | |
| Clarithromycin SCHEMBL24064961 | 1.00 | CYP3A4 (1.00) | CYP3A4KCNH2ABCB1SLCO1B3SLCO1B1 | |
| Clarithromycin SCHEMBL15474392 | 1.00 | CYP3A4 (1.00) | CYP3A4KCNH2ABCB1SLCO1B3SLCO1B1 | |
| Clarithromycin SCHEMBL23309064 | 1.00 | CYP3A4 (1.00) | CYP3A4KCNH2ABCB1SLCO1B3SLCO1B1 | |
| Clarithromycin SCHEMBL14342512 | 1.00 | CYP3A4 (1.00) | CYP3A4KCNH2ABCB1SLCO1B3SLCO1B1 | |
| Clarithromycin SCHEMBL23854898 | 1.00 | CYP3A4 (1.00) | CYP3A4KCNH2ABCB1SLCO1B3SLCO1B1 | |
| Clarithromycin SCHEMBL38124 | 1.00 | CYP3A4 (1.00) | CYP3A4KCNH2ABCB1SLCO1B3SLCO1B1 | |
| Clarithromycin SCHEMBL14495684 | 1.00 | CYP3A4 (1.00) | CYP3A4KCNH2ABCB1SLCO1B3SLCO1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394813-B2 | Active agent delivery systems and methods for protecting and administering active agents | SHIRE LLC (US) | 2013-03-12 | — | — | US | disclosed |
| US-20090306228-A1 | ACTIVE AGENT DELIVERY SYSTEMS AND METHODS FOR PROTECTING AND ADMINISTERING ACTIVE AGENTS | SHIRE LLC (US) | 2009-12-10 | — | — | US | disclosed |
| US-20090253792-A1 | ACTIVE AGENT DELIVERY SYSTEMS AND METHODS FOR PROTECTING AND ADMINISTERING ACTIVE AGENTS | SHIRE LLC (US) | 2009-10-08 | — | — | US | disclosed |
| US-7427600-B2 | Active agent delivery systems and methods for protecting and administering active agents | SHIRE LLC (US) | 2008-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253792-A1 | ACTIVE AGENT DELIVERY SYSTEMS AND METHODS FOR PROTECTING AND ADMINISTERING ACTIVE AGENTS | HDGF, CTSA, IAPP | CYP3A4 4785/4885KCNH2 4861/4885ABCB1 698/4885 |
| US-20090306228-A1 | ACTIVE AGENT DELIVERY SYSTEMS AND METHODS FOR PROTECTING AND ADMINISTERING ACTIVE AGENTS | HDGF, CTSA, IAPP | CYP3A4 4785/4885KCNH2 4861/4885ABCB1 698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.