Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.65 |
| ▸ | HTR2A | P28223 | 2/20 | 0.65 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.65 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.65 |
| ▸ | SCN1A | P35498 | 1/20 | 0.65 |
| ▸ | HTR2B | P41595 | 1/20 | 0.65 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.65 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | HRH1 | P35367 | 3/20 | 0.60 |
| ▸ | HRH2 | P25021 | 2/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21659595 | 0.93 | NPC1 (0.58) | HRH3MAPK1KCNH2HTR2ASIGMAR1 | |
| SCHEMBL3580274 | 0.89 | HRH3 (0.78) | HRH3KCNH2HTR2ASIGMAR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3569842 | 0.87 | HRH3 (0.76) | HRH3KCNH2HTR2ASIGMAR1ALDH1A1 | |
| SCHEMBL13437926 | 0.87 | HRH3 (0.81) | HRH3KCNH2ALDH1A1HRH1HRH2 | |
| SCHEMBL3573919 | 0.87 | HRH3 (0.81) | HRH3KCNH2ALDH1A1HRH1HRH2 | |
| SCHEMBL3584179 | 0.87 | HRH3 (0.81) | HRH3KCNH2ALDH1A1HRH1HRH2 | |
| SCHEMBL21659286 | 0.86 | HRH3 (0.66) | HRH3KCNH2HTR2ASIGMAR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3581472 | 0.86 | HRH3 (0.78) | HRH3KCNH2ALDH1A1HRH1HRH2 | |
| Hydrochloric Acid SCHEMBL23855511 | 0.85 | HRH3 (0.64) | HRH3MAPK1KCNH2HTR2ASIGMAR1 | |
| SCHEMBL3576424 | 0.84 | HRH3 (0.79) | HRH3KCNH2HTR2ASIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210300936-A1 | PYRAZOLOTRIAZOLOPYRIMIDINE DERIVATIVES AS A2A RECEPTOR ANTAGONIST | BEONE MEDICINES I GMBH (CH) | 2021-09-30 | — | — | US | disclosed |
| CN-112469722-A | Pyrazolo-triazolopyrimidine derivatives as A2A receptor antagonists | 百济神州有限公司 | 2021-03-09 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210300936-A1 | PYRAZOLOTRIAZOLOPYRIMIDINE DERIVATIVES AS A2A RECEPTOR ANTAGONIST | ADORA2A, ADORA3, ADORA2B | HRH3 673/4885MAPK1 3717/4885KCNH2 1642/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.