Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23856774 | 1.00 | ALDH1A1 (0.44) | ALDH1A1KMT2ASMN1; SMN2NPSR1NR3C2 | |
| SCHEMBL23871554 | 0.87 | TRPV1 (0.40) | ALDH1A1KMT2ASMN1; SMN2NPSR1NR3C2 | |
| SCHEMBL23856492 | 0.87 | TRPV1 (0.40) | ALDH1A1KMT2ASMN1; SMN2NPSR1NR3C2 | |
| SCHEMBL30253214 | 0.87 | TRPV1 (0.40) | ALDH1A1KMT2ASMN1; SMN2NPSR1NR3C2 | |
| SCHEMBL23856495 | 0.87 | TRPV1 (0.40) | ALDH1A1KMT2ASMN1; SMN2NPSR1NR3C2 | |
| SCHEMBL23857400 | 0.85 | ALDH1A1 (0.48) | ALDH1A1KMT2ASMN1; SMN2NPSR1NR3C2 | |
| SCHEMBL23857466 | 0.85 | ALDH1A1 (0.48) | ALDH1A1KMT2ASMN1; SMN2NPSR1NR3C2 | |
| SCHEMBL23871493 | 0.85 | ALDH1A1 (0.48) | ALDH1A1KMT2ASMN1; SMN2NPSR1NR3C2 | |
| SCHEMBL23857399 | 0.85 | ALDH1A1 (0.48) | ALDH1A1KMT2ASMN1; SMN2NPSR1NR3C2 | |
| SCHEMBL23857464 | 0.85 | ALDH1A1 (0.48) | ALDH1A1KMT2ASMN1; SMN2NPSR1NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4126855-B1 | COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS | HOFFMANN LA ROCHE (CH) | 2024-04-24 | — | — | EP | disclosed |
| US-20230167127-A1 | COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTION | HOFFMANN-LA ROCHE INC. (US) | 2023-06-01 | — | — | US | disclosed |
| EP-4126855-A1 | COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTION | F. Hoffmann-La Roche AG (CH) | 2023-02-08 | — | — | EP | disclosed |
| WO-2021190727-A1 | COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2021-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230167127-A1 | COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTION | LTB4R, C5, C3AR1 | ALDH1A1 842/4885KMT2A 3563/4885SMN1; SMN2 4067/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.