Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.57 |
| ▸ | NPC1 | O15118 | 7/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6399265 | 0.84 | HDAC4 (0.77) | SMN1; SMN2NPC1HDAC3HDAC4HDAC1 | |
| SCHEMBL7432797 | 0.81 | SMN1; SMN2 (0.51) | RAB9ASMN1; SMN2NPC1HDAC3HDAC4 | |
| SCHEMBL11221078 | 0.81 | SMN1; SMN2 (0.64) | RAB9ASMN1; SMN2NPC1HTTKMT2A | |
| SCHEMBL7444667 | 0.81 | SMN1; SMN2 (0.62) | RAB9ASMN1; SMN2NPC1HTTKMT2A | |
| SCHEMBL2562988 | 0.79 | SMN1; SMN2 (0.59) | RAB9ASMN1; SMN2NPC1HTTKMT2A | |
| SCHEMBL10438791 | 0.79 | MME (0.54) | RAB9ASMN1; SMN2NPC1KMT2AMAPT | |
| SCHEMBL10438787 | 0.79 | MME (0.54) | RAB9ASMN1; SMN2NPC1KMT2AMAPT | |
| SCHEMBL7433072 | 0.79 | SMN1; SMN2 (0.54) | RAB9ASMN1; SMN2NPC1HDAC3HDAC4 | |
| SCHEMBL5145754 | 0.78 | KMT2A (0.62) | RAB9ASMN1; SMN2NPC1HTTKMT2A | |
| SCHEMBL7567258 | 0.78 | SMN1; SMN2 (0.69) | RAB9ASMN1; SMN2NPC1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4126833-B1 | N-PHENYL-3-MERCAPTOPROPANAMIDE DERIVATIVES AS METALLO-BETA-LACTAMASE INHIBITORS FOR THE TREATMENT OF BACTERIAL INFECTIONS | HELMHOLTZ ZENTRUM INFEKTIONSFORSCHUNG GMBH (DE) | 2026-05-20 | — | — | EP | disclosed |
| US-12616670-B2 | N-phenyl-3-mercaptopropanamide derivatives as metallo-beta-lactamase inhibitors for the treatment of bacterial infections | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2026-05-05 | — | — | US | disclosed |
| US-20230146507-A1 | N-PHENYL-3-MERCAPTOPROPANAMIDE DERIVATIVES AS METALLO-BETA-LACTAMASE INHIBITORS FOR THE TREATMENT OF BACTERIAL INFECTIONS | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2023-05-11 | — | — | US | disclosed |
| EP-4126833-A1 | N-PHENYL-3-MERCAPTOPROPANAMIDE DERIVATIVES AS METALLO-BETA-LACTAMASE INHIBITORS FOR THE TREATMENT OF BACTERIAL INFECTIONS | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2023-02-08 | — | — | EP | disclosed |
| WO-2021191219-A1 | N-PHENYL-3-MERCAPTOPROPANAMIDE DERIVATIVES AS METALLO-BETA-LACTAMASE INHIBITORS FOR THE TREATMENT OF BACTERIAL INFECTIONS | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2021-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12616670-B2 | N-phenyl-3-mercaptopropanamide derivatives as metallo-beta-lactamase inhibitors for the treatment of bacterial infections | CPN1, MME, ANPEP | RAB9A 2816/4885SMN1; SMN2 1495/4885NPC1 507/4885 |
| US-20230146507-A1 | N-PHENYL-3-MERCAPTOPROPANAMIDE DERIVATIVES AS METALLO-BETA-LACTAMASE INHIBITORS FOR THE TREATMENT OF BACTERIAL INFECTIONS | MGAM, PREP, MME | RAB9A 1744/4885SMN1; SMN2 3392/4885NPC1 2634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.