Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 3/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | BCL6 | P41182 | 1/20 | 0.44 |
| ▸ | FADS1 | O60427 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30279685 | 1.00 | GRM4 (0.48) | GRM4GRM5HSD17B14POLBMAPT | |
| SCHEMBL20206220 | 0.81 | DDX3X (0.54) | GRM4GRM5POLBMAPTSMN1; SMN2 | |
| SCHEMBL20766926 | 0.80 | MAPT (0.65) | GRM5POLBMAPTBCL6NPC1 | |
| SCHEMBL20189462 | 0.80 | POLB (0.56) | GRM5POLBMAPTBCL6NPC1 | |
| SCHEMBL30279679 | 0.80 | MEN1 (0.47) | GRM4GRM5HSD17B14POLBMAPT | |
| SCHEMBL23860710 | 0.80 | MEN1 (0.47) | GRM4GRM5HSD17B14POLBMAPT | |
| SCHEMBL17448379 | 0.76 | POLB (0.57) | GRM4HSD17B14POLBMAPTNPC1 | |
| SCHEMBL20189793 | 0.76 | POLB (0.62) | GRM5POLBMAPTBCL6NPC1 | |
| SCHEMBL24021474 | 0.75 | MAPT (0.56) | GRM5POLBMAPTNPC1RAB9A | |
| SCHEMBL17152729 | 0.74 | SMN1; SMN2 (0.56) | GRM5POLBMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240043405-A1 | POTENT AND SELECTIVE IRREVERSIBLE INHIBITORS OF IRAK1 | DANA-FARBER CANCER INSTITUTE, INC. | 2024-02-08 | — | — | US | disclosed |
| EP-4125895-A1 | POTENT AND SELECTIVE IRREVERSIBLE INHIBITORS OF IRAK1 | Dana-Farber Cancer Institute, Inc. (US) | 2023-02-08 | — | — | EP | disclosed |
| CN-115484954-A | Potent and selective irreversible inhibitors of IRAK1 | 达纳-法伯癌症研究所股份有限公司 | 2022-12-16 | — | — | CN | disclosed |
| WO-2021194982-A1 | POTENT AND SELECTIVE IRREVERSIBLE INHIBITORS OF IRAK1 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240043405-A1 | POTENT AND SELECTIVE IRREVERSIBLE INHIBITORS OF IRAK1 | IRAK1, IRAK2, IRAK3 | GRM4 3020/4885GRM5 2994/4885HSD17B14 4262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.