Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDX3X | O00571 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GRM5 | P41594 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.49 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20189462 | 0.85 | POLB (0.56) | POLBGRM5ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL16430837 | 0.84 | DDX3X (0.56) | DDX3XPOLBALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL23860735 | 0.81 | GRM4 (0.48) | POLBGRM5ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL30279685 | 0.81 | GRM4 (0.48) | POLBGRM5ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL3087891 | 0.79 | GRM4 (0.70) | DDX3XSMN1; SMN2KDRGRM4HDAC6 | |
| SCHEMBL20189793 | 0.77 | POLB (0.62) | POLBGRM5ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL12468912 | 0.77 | POLB (0.57) | POLBGRM5ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL24021474 | 0.77 | MAPT (0.56) | POLBGRM5ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL26872446 | 0.77 | CYP11B2 (0.58) | POLBGRM5ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL16441860 | 0.76 | DDX3X (0.50) | DDX3XPOLBALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018098367-A1 | INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-05-31 | — | — | WO | disclosed |