Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | AKT2 | P31751 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL871865 | 0.79 | CA1 (0.52) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL871688 | 0.78 | CA1 (0.50) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL18662857 | 0.76 | AKT1 (0.50) | ALDH1A1MAPTAKT1AKT2CA1 | |
| SCHEMBL24861978 | 0.76 | AKT1 (0.53) | ALDH1A1MAPTAKT1AKT2CA1 | |
| SCHEMBL19343293 | 0.75 | MEN1 (0.53) | ALDH1A1HPGDCYP2D6MAPTMEN1 | |
| SCHEMBL2109932 | 0.74 | STS (0.49) | ALDH1A1HPGDRAB9AMAPTAKT1 | |
| SCHEMBL19331211 | 0.73 | ALDH1A1 (0.50) | ALDH1A1HPGDALOX15MGLLHSD17B10 | |
| SCHEMBL19343523 | 0.72 | NPC1 (0.48) | ALDH1A1HPGDALOX15MGLLHSD17B10 | |
| SCHEMBL647915 | 0.71 | CRBN (0.53) | CRBNALDH1A1HPGDALOX15MGLL | |
| SCHEMBL20491450 | 0.71 | RORC (0.44) | ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3884939-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | Raze Therapeutics, Inc. (US) | 2021-09-29 | — | — | EP | disclosed |