Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 8/20 | 0.59 |
| ▸ | AXL | P30530 | 6/20 | 0.59 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.53 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | MET | P08581 | 4/20 | 0.49 |
| ▸ | WNT1 | P04628 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.47 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.47 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.47 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.46 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18615853 | 0.88 | AXL (0.57) | MERTKAXLMAP4K3FGFR1FGFR2 | |
| SCHEMBL2386565 | 0.88 | AXL (0.59) | MERTKAXLMAP4K3FGFR1FGFR2 | |
| SCHEMBL2387035 | 0.87 | MAP4K3 (0.68) | MERTKAXLMAP4K3NTRK1MET | |
| SCHEMBL2386492 | 0.87 | AXL (0.56) | MERTKAXLMAP4K3FGFR1FGFR2 | |
| Hydrochloric Acid SCHEMBL2385615 | 0.87 | AXL (0.59) | MERTKAXLMAP4K3FGFR1FGFR2 | |
| Hydrochloric Acid SCHEMBL2386496 | 0.87 | AXL (0.59) | MERTKAXLMAP4K3FGFR1FGFR2 | |
| SCHEMBL2385504 | 0.86 | MET (0.53) | MERTKAXLMAP4K3FGFR1FGFR2 | |
| SCHEMBL18591563 | 0.81 | IKBKE (0.62) | MERTKAXLMETIKBKETBK1 | |
| SCHEMBL2388397 | 0.81 | AXL (0.56) | MERTKAXLMAP4K3FGFR1FGFR2 | |
| SCHEMBL2387892 | 0.81 | MERTK (0.57) | MERTKAXLMAP4K3FGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017611-B2 | Pyridine and pyrazine derivatives -083 | ASTRAZENECA AB (SE) | 2011-09-13 | — | — | US | disclosed |
| EP-2215085-B1 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2011-09-07 | — | — | EP | disclosed |
| EP-2215085-A2 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2010-08-11 | — | — | EP | disclosed |
| US-20090118305-A1 | PYRIDINE AND PYRAZINE DERIVATIVES - 083 | ASTRAZENECA AB (SE) | 2009-05-07 | — | — | US | disclosed |
| WO-2009053737-A2 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2009-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118305-A1 | PYRIDINE AND PYRAZINE DERIVATIVES - 083 | MKI67, CCND3, CCND1 | MERTK 3823/4885AXL 2302/4885MAP4K3 102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.