Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 4/20 | 0.56 |
| ▸ | MERTK | Q12866 | 4/20 | 0.56 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.54 |
| ▸ | MET | P08581 | 7/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.50 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.48 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.47 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.47 |
| ▸ | MST1R | Q04912 | 1/20 | 0.47 |
| ▸ | WNT1 | P04628 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18615853 | 0.90 | AXL (0.57) | AXLMERTKMAP4K3METNTRK1 | |
| SCHEMBL2386565 | 0.90 | AXL (0.59) | AXLMERTKMAP4K3METNTRK1 | |
| Hydrochloric Acid SCHEMBL2385615 | 0.89 | AXL (0.59) | AXLMERTKMAP4K3METNTRK1 | |
| Hydrochloric Acid SCHEMBL2386496 | 0.89 | AXL (0.59) | AXLMERTKMAP4K3METNTRK1 | |
| SCHEMBL2386302 | 0.87 | MERTK (0.59) | AXLMERTKMAP4K3METNTRK1 | |
| SCHEMBL29914439 | 0.82 | MET (0.55) | AXLMERTKMAP4K3METNTRK1 | |
| SCHEMBL23617090 | 0.80 | MET (0.55) | AXLMERTKMAP4K3METNTRK1 | |
| SCHEMBL30388408 | 0.80 | MET (0.55) | AXLMERTKMAP4K3METNTRK1 | |
| SCHEMBL21776509 | 0.80 | MET (0.55) | AXLMERTKMAP4K3METNTRK1 | |
| SCHEMBL4089510 | 0.80 | MET (0.55) | AXLMERTKMAP4K3METNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017611-B2 | Pyridine and pyrazine derivatives -083 | ASTRAZENECA AB (SE) | 2011-09-13 | — | — | US | disclosed |
| EP-2215085-B1 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2011-09-07 | — | — | EP | disclosed |
| US-20090118305-A1 | PYRIDINE AND PYRAZINE DERIVATIVES - 083 | ASTRAZENECA AB (SE) | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118305-A1 | PYRIDINE AND PYRAZINE DERIVATIVES - 083 | MKI67, CCND3, CCND1 | AXL 2302/4885MERTK 3823/4885MAP4K3 102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.