Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL245209 | 0.79 | MAPT (0.50) | NPC1RAB9AANPEPGAAKMT2A | |
| SCHEMBL23351400 | 0.77 | TDP1 (0.48) | GAAMEN1KMT2ANPSR1HPGD | |
| SCHEMBL19399594 | 0.74 | MAPT (0.45) | NPC1RAB9AANPEPGAAKMT2A | |
| SCHEMBL17716129 | 0.74 | MAPT (0.45) | NPC1RAB9AANPEPGAAKMT2A | |
| SCHEMBL2230553 | 0.71 | NPC1 (0.48) | NPC1RAB9AGAAHPGDALDH1A1 | |
| SCHEMBL26385190 | 0.71 | NPC1 (0.48) | NPC1RAB9AGAAHPGDALDH1A1 | |
| SCHEMBL30461968 | 0.71 | MAPT (0.50) | NPC1RAB9AGAAKMT2AHPGD | |
| SCHEMBL4750832 | 0.71 | MAPT (0.50) | NPC1RAB9AGAAKMT2AHPGD | |
| SCHEMBL18904614 | 0.67 | MAPT (0.46) | NPC1RAB9AGAAMEN1KMT2A | |
| SCHEMBL22643737 | 0.67 | MAPT (0.46) | NPC1RAB9AGAAKMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3885344-A2 | PYRIMIDINE COMPOUNDS, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USES THEREOF | InventisBio Co., Ltd. (CN) | 2021-09-29 | — | — | EP | disclosed |