Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | GFER | P55789 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14923964 | 0.86 | MAPT (0.59) | MAPTALDH1A1KDM4EL3MBTL1GFER | |
| SCHEMBL5741708 | 0.86 | MAPT (0.66) | MAPTALDH1A1KDM4EL3MBTL1GFER | |
| SCHEMBL20251137 | 0.84 | MAPT (0.51) | MAPTALDH1A1KDM4EL3MBTL1GFER | |
| SCHEMBL10169299 | 0.84 | MAPT (0.68) | MAPTALDH1A1KDM4EL3MBTL1GFER | |
| SCHEMBL15496525 | 0.83 | HTR1A (0.50) | MAPTALDH1A1KDM4EGFERLMNA | |
| SCHEMBL6245192 | 0.82 | IGF1R (0.56) | MAPTALDH1A1KDM4EL3MBTL1GFER | |
| SCHEMBL12535863 | 0.82 | IGF1R (0.56) | MAPTALDH1A1KDM4EL3MBTL1GFER | |
| SCHEMBL2767049 | 0.82 | KDM4E (0.61) | MAPTALDH1A1KDM4EL3MBTL1GFER | |
| SCHEMBL1100438 | 0.81 | ALDH1A1 (0.72) | MAPTALDH1A1KDM4EL3MBTL1GFER | |
| SCHEMBL21655007 | 0.81 | MEN1 (0.53) | MAPTALDH1A1KDM4EL3MBTL1GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689871-B1 | 4,6,7-TRISUBSTITUTED 1,2-DIHYDROPYRROL[3,4-C]PYRIDIN/PYRIMIDIN-3-ONE DERIVATIVE AND USE | SHANGHAI HAIYAN PHARMACEUTICAL TECH CO LTD (CN) | 2021-09-29 | — | — | EP | disclosed |