Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 0.47 |
| ▸ | HTR2A | P28223 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 3/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23867516 | 0.89 | POLB (0.53) | POLBSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL23867525 | 0.85 | HTR2A (0.49) | POLBHTR2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL23867514 | 0.84 | POLB (0.50) | POLBHTR2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL23867474 | 0.83 | SRC (0.51) | POLBHTR2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL23867479 | 0.79 | POLB (0.49) | POLBSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL23867519 | 0.76 | HTR2A (0.51) | HTR2AHTR2CSRCEGFRALDH1A1 | |
| SCHEMBL30234578 | 0.74 | POLB (0.52) | POLBSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL23867477 | 0.74 | POLB (0.52) | POLBSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL23867475 | 0.72 | POLB (0.55) | POLBSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL23867574 | 0.71 | PYGM (0.53) | HTR2AHTR2CSRCDRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021195279-A2 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTAL CANCER | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2021-09-30 | — | — | WO | disclosed |